Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0716 | 0.4073 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1729 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.1758 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0117 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0117 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0117 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0592 | 0.3364 |
Trichomonas vaginalis | hypothetical protein | 0.1729 | 1 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0117 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0117 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0117 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1729 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1729 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0117 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0117 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1729 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1729 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1729 | 1 | 1 |
Onchocerca volvulus | 0.0117 | 0 | 0.5 | |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0117 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0117 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0117 | 0 | 0.5 |
Onchocerca volvulus | 0.0117 | 0 | 0.5 | |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0232 | 0.0716 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1729 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Rice stem length (functional) | ~ 2.6 cm | Compound was tested for its activity in rice stem elongation test at a concentration of 1 microM. Stem length was measured after 7 days of transplantation | ChEMBL. | 10091696 |
Rice stem length (functional) | ~ 2.6 cm | Compound was tested for its activity in rice stem elongation test at a concentration of 1 microM. Stem length was measured after 7 days of transplantation | ChEMBL. | 10091696 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.