Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 uM | Cytotoxicity of the compound against MCF-7 cell line in the purdue cell culture screen was determined; NT=not tested | ChEMBL. | 10091695 |
ED50 (functional) | 0 uM | Cytotoxicity of the compound against MCF-7ADR cell line in the purdue cell culture screen was determined; NT=not tested | ChEMBL. | 10091695 |
ED50 (functional) | = 0.34 uM | Cytotoxicity against A-549 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 0.34 uM | Cytotoxicity against A-549 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 0.4 uM | Cytotoxicity against PC-3 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 0.4 uM | Cytotoxicity against PC-3 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 0.58 uM | Cytotoxicity against HT-29 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 0.58 uM | Cytotoxicity against HT-29 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 1.2 uM | Cytotoxicity against PACA-2 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 1.2 uM | Cytotoxicity against PACA-2 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 1.3 uM | Cytotoxicity against A-498 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 1.3 uM | Cytotoxicity against A-498 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 1.6 uM | Cytotoxicity against MCF-7R cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 1.6 uM | Cytotoxicity against MCF-7R cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.