Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0363 | 0.2977 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0298 | 0.2344 | 0.3627 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.2977 | 0.4606 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.1613 | 0.3229 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0337 | 0.2732 | 0.7125 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2344 | 0.3627 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0444 | 0.3776 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.066 | 0.5881 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.313 | 0.4844 |
Brugia malayi | Matrixin family protein | 0.072 | 0.6462 | 1 |
Onchocerca volvulus | 0.0422 | 0.3558 | 0.3431 | |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0363 | 0.2977 | 0.4606 |
Schistosoma mansoni | hypothetical protein | 0.0422 | 0.3558 | 1 |
Brugia malayi | Matrixin family protein | 0.0298 | 0.2344 | 0.3627 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2344 | 0.3627 |
Loa Loa (eye worm) | matrixin family protein | 0.072 | 0.6462 | 1 |
Brugia malayi | Matrixin family protein | 0.0298 | 0.2344 | 0.3627 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.2174 | 0.1598 |
Onchocerca volvulus | Matrilysin homolog | 0.066 | 0.5881 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0444 | 0.3776 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0363 | 0.2977 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0138 | 0.0785 | 0.0107 |
Brugia malayi | Hemopexin family protein | 0.0422 | 0.3558 | 0.5505 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2344 | 0.3627 |
Leishmania major | squalene monooxygenase-like protein | 0.0444 | 0.3776 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0298 | 0.2344 | 0.3627 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.0785 | 0.0348 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.0785 | 0.0348 |
Loa Loa (eye worm) | matrixin family protein | 0.066 | 0.5881 | 0.9101 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1082 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0298 | 0.2344 | 0.5774 |
Brugia malayi | Matrixin family protein | 0.0298 | 0.2344 | 0.3627 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0363 | 0.2977 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.313 | 0.4844 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0444 | 0.3776 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.2174 | 0.1598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.