Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.0257 | 0.5874 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0257 | 0.5874 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0367 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0257 | 0.5874 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0257 | 0.5874 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0214 | 0.4243 | 0.7223 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0257 | 0.5874 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0257 | 0.5874 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0367 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0257 | 0.5874 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0257 | 0.5874 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0367 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0367 | 1 | 1 |
Onchocerca volvulus | 0.0214 | 0.4243 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0367 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0214 | 0.4243 | 0.7223 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0257 | 0.5874 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0257 | 0.5874 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MCC (functional) | > 80 ug ml-1 | Minimal cytotoxic concentration(MCC) to cause a microscopically detectable change in normal cell morphology | ChEMBL. | 11708929 |
MIC (functional) | = 0.005 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against KOS strain of human Herpes Simplex Virus -1 | ChEMBL. | 11708929 |
MIC (functional) | = 0.005 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against F strain of human Herpes Simplex Virus-1 (HSV-1) | ChEMBL. | 11708929 |
MIC (functional) | = 0.005 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against McIntyre strain of human Herpes Simplex Virus-1 | ChEMBL. | 11708929 |
MIC (functional) | = 0.02 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against Lyons strain of human Herpes Simplex Virus-2 | ChEMBL. | 11708929 |
MIC (functional) | = 0.03 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against G strain of human Herpes Simplex Virus-2 | ChEMBL. | 11708929 |
MIC (functional) | = 0.04 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against TK-/TK+ HSV-1 of VMW 837 | ChEMBL. | 11708929 |
MIC (functional) | = 0.08 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against 196 strain of human Herpes Simplex Virus-2 | ChEMBL. | 11708929 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against Thymidine kinase deficient(TK-) HSV-1 of Acyclovir | ChEMBL. | 11708929 |
MIC (functional) | > 80 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against VV | ChEMBL. | 11708929 |
MIC (functional) | > 80 ug ml-1 | Minimal inhibitory concentration to reduce virus-induced cytopathicity against VSV | ChEMBL. | 11708929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.