Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0069 | 0 | 0.5 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0069 | 0 | 0.5 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0069 | 0 | 0.5 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0303 | 1 | 1 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.0114 | 0.1902 | 1 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Brugia malayi | POT family protein | 0.0085 | 0.0699 | 0.0699 |
Loa Loa (eye worm) | subtilase | 0.0303 | 1 | 1 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.0114 | 0.1902 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | POT family protein | 0.0085 | 0.0699 | 0.0699 |
Onchocerca volvulus | Peroxidase homolog | 0.0069 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0069 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 11 uM | Ability to inhibit N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated release of myeloperoxidase (MPO) from rat polymorphonuclear leukocytes (PMN). | ChEMBL. | 7996547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.