Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 0.3418 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0054 | 0.0592 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0175 | 0.5132 | 0.6516 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0083 | 0.1675 | 0.2382 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.2661 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0175 | 0.5132 | 0.5 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0226 | 0.7033 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.2661 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0054 | 0.0592 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0083 | 0.1675 | 0.3418 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0175 | 0.5132 | 0.5651 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0175 | 0.5132 | 0.7267 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0057 | 0.0679 | 0.1386 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.011 | 0.2661 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0175 | 0.5132 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0054 | 0.0592 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0083 | 0.1675 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0081 | 0.1574 | 0.2154 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0169 | 0.4901 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.2661 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0169 | 0.4901 | 1 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0057 | 0.0679 | 0.1386 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.4901 | 0.6094 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1365 | 0.1854 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 0.3418 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0169 | 0.4901 | 1 |
Onchocerca volvulus | 0.0081 | 0.1574 | 0.1511 | |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0226 | 0.7033 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0226 | 0.7033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1574 | 0.2154 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 0.3418 |
Onchocerca volvulus | 0.0081 | 0.1574 | 0.1511 | |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0175 | 0.5132 | 0.7267 |
Treponema pallidum | DNA polymerase I (polA) | 0.0054 | 0.0592 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.4901 | 0.6094 |
Mycobacterium ulcerans | DNA polymerase I | 0.0054 | 0.0592 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0175 | 0.5132 | 0.5 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0057 | 0.0679 | 0.1386 |
Onchocerca volvulus | 0.0081 | 0.1574 | 0.1511 | |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0226 | 0.7033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1574 | 0.2154 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 0.2382 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0175 | 0.5132 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.0222 | 0.6872 | 0.9768 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0175 | 0.5132 | 0.6516 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0175 | 0.5132 | 0.5651 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0054 | 0.0592 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0226 | 0.7033 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0226 | 0.7033 | 1 |
Plasmodium falciparum | topoisomerase I | 0.0226 | 0.7033 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.0226 | 0.7033 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC200 (functional) | > 10 uM | Effect on the formation of protein-DNA complex in P388 cells K+/SDS method | ChEMBL. | 10340602 |
EC200 (functional) | > 10 uM | Effect on the formation of protein-DNA complex in P388 cells K+/SDS method | ChEMBL. | 10340602 |
EC50 (functional) | = 9.5 uM | In vitro activity against topoisomerase-I mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
EC50 (functional) | = 9.5 uM | In vitro activity against topoisomerase-I mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
EC50 (functional) | > 50 uM | In vitro activity against topoisomerase-II mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
EC50 (functional) | > 50 uM | In vitro activity against topoisomerase-II mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
IC50 (functional) | = 0.8 uM | In vitro cytotoxicity (CTX) against murine leukemia cells (P388) using colorimeric tetrazolium-formazan method | ChEMBL. | 10340602 |
IC50 (functional) | = 0.8 uM | In vitro cytotoxicity (CTX) against murine leukemia cells (P388) using colorimeric tetrazolium-formazan method | ChEMBL. | 10340602 |
IC50 (functional) | = 2.9 uM | In vitro cytotoxicity (CTX) against human stomach cancer cells (MKN-45) using sulforhodamine B dye-staining method | ChEMBL. | 10340602 |
IC50 (functional) | = 2.9 uM | In vitro cytotoxicity (CTX) against human stomach cancer cells (MKN-45) using sulforhodamine B dye-staining method | ChEMBL. | 10340602 |
IC50 (binding) | = 110 uM | In vitro activity evaluated against protein kinase C (using histone II-As as a substrate) | ChEMBL. | 10340602 |
IC50 (binding) | = 110 uM | In vitro activity evaluated against protein kinase C (using histone II-As as a substrate) | ChEMBL. | 10340602 |
IC50 (binding) | > 200 uM | In vitro activity against Epidermal growth factor receptor (using poly(Glu4Tyr1) as a substrate) | ChEMBL. | 10340602 |
IC50 (binding) | > 200 uM | In vitro activity against Epidermal growth factor receptor (using poly(Glu4Tyr1) as a substrate) | ChEMBL. | 10340602 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10340602 | |
Mus musculus | ChEMBL23 | 10340602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.