Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0623 | 0.5 | 0.5 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0623 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0623 | 0.5 | 0.5 | |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0623 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0623 | 0.5 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0623 | 0.5 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0623 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (functional) | = 4.6 | Agonistic activity tested against histamine H2 receptor on guinea pig atrium | ChEMBL. | 8632428 |
-Log KB (functional) | = 5.9 | Agonistic activity tested against histamine H1 receptor on guinea pig ileum | ChEMBL. | 8632428 |
-Log KB (functional) | = 4.6 | Agonistic activity tested against histamine H2 receptor on guinea pig atrium | ChEMBL. | 8632428 |
-Log KB (functional) | = 5.9 | Agonistic activity tested against histamine H1 receptor on guinea pig ileum | ChEMBL. | 8632428 |
-Log Ki (functional) | = 6.8 | In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex | ChEMBL. | 8632428 |
-Log Ki (binding) | = 7.5 | Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex | ChEMBL. | 8632428 |
Ki (functional) | = 6.8 | In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex | ChEMBL. | 8632428 |
Ki (binding) | = 7.5 | Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex | ChEMBL. | 8632428 |
Ki (functional) | = 146 nM | In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex | ChEMBL. | 8632428 |
Ki (functional) | = 146 nM | In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex | ChEMBL. | 8632428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.