Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0106 | 0 | 0.5 |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.0226 | 0.4978 | 0.4978 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2681 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0106 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0106 | 0 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0106 | 0 | 0.5 |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.0346 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 28 | 0.0346 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.2681 | 0.2681 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.0346 | 1 | 1 |
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.0346 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2681 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0106 | 0 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0106 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2681 | 0.2681 |
Giardia lamblia | Glycogen phosphorylase | 0.0106 | 0 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0106 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0106 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.2 uM | In vitro cytotoxicity against HT-29 (human colon carcinoma) cell line. | ChEMBL. | 14971901 |
IC50 (functional) | = 0.2 uM | In vitro cytotoxicity against HT-29 (human colon carcinoma) cell line. | ChEMBL. | 14971901 |
IC50 (functional) | = 0.9 uM | Tested in vitro for antineoplastic activity against P-388 (lymphoid neoplasm from DBA/2 mouse) tumor cell line | ChEMBL. | 14971901 |
IC50 (functional) | = 0.9 uM | In vitro cytotoxicity against A-549 (human lung carcinoma) cell line. | ChEMBL. | 14971901 |
IC50 (functional) | = 0.9 uM | Tested in vitro for antineoplastic activity against MEL-28 (human melanoma) tumor cell line | ChEMBL. | 14971901 |
IC50 (functional) | = 0.9 uM | Tested in vitro for antineoplastic activity against P-388 (lymphoid neoplasm from DBA/2 mouse) tumor cell line | ChEMBL. | 14971901 |
IC50 (functional) | = 0.9 uM | In vitro cytotoxicity against A-549 (human lung carcinoma) cell line. | ChEMBL. | 14971901 |
IC50 (functional) | = 0.9 uM | Tested in vitro for antineoplastic activity against MEL-28 (human melanoma) tumor cell line | ChEMBL. | 14971901 |
Selectivity index (functional) | = 4.5 | Selectivity index is the ratio of IC50 of P-388 cell line to that of HT-29 | ChEMBL. | 14971901 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 14971901 | |
Mus musculus | ChEMBL23 | 14971901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.