Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.2391 | 1 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0217 | 0.286 | 0.286 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0185 | 0.2391 | 0.2391 |
Onchocerca volvulus | 0.0333 | 0.4591 | 0.9096 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0237 | 0.3157 | 0.3157 |
Schistosoma mansoni | kinase | 0.0356 | 0.4922 | 0.4922 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.2391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0271 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0152 | 0.0293 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0185 | 0.2391 | 0.4599 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0185 | 0.2391 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0034 | 0.0152 | 0.0152 |
Echinococcus multilocularis | roundabout 2 | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0271 | 0.0522 |
Trypanosoma brucei | polo-like protein kinase | 0.0185 | 0.2391 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0185 | 0.2391 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0032 | 0.0119 | 0.0119 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0698 | 1 | 1 |
Loa Loa (eye worm) | raf kinase | 0.023 | 0.3057 | 0.5881 |
Schistosoma mansoni | nephrin | 0.0032 | 0.0119 | 0.0119 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0185 | 0.2391 | 0.2391 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0015 | 0.0015 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.2391 | 1 |
Brugia malayi | Raf kinase | 0.0229 | 0.3037 | 0.5842 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.2391 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.2391 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0237 | 0.3157 | 0.3157 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0374 | 0.5198 | 1 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0217 | 0.286 | 0.286 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0185 | 0.2391 | 0.5 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0237 | 0.3157 | 0.3157 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0185 | 0.2391 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0185 | 0.2391 | 0.4599 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.2391 | 0.2391 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.2391 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0348 | 0.481 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0698 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.0032 | 0.0119 | 0.0119 |
Echinococcus granulosus | twitchin | 0.0033 | 0.0133 | 0.0133 |
Schistosoma mansoni | cell adhesion molecule | 0.0034 | 0.0152 | 0.0152 |
Echinococcus granulosus | roundabout 2 | 0.0042 | 0.0271 | 0.0271 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.2391 | 1 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0137 | 0.1672 | 0.3216 |
Giardia lamblia | Kinase, PLK | 0.0185 | 0.2391 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0374 | 0.5198 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CF (binding) | = 6.9 | Competition factor for Thromboxane A2 receptor binding affinity CF = (IC50-test)/(IC50-standard) | ChEMBL. | No reference |
CF (binding) | = 6.9 | Competition factor for Thromboxane A2 receptor binding affinity CF = (IC50-test)/(IC50-standard) | ChEMBL. | No reference |
IC50 (functional) | = 17 uM | Inhibition of ADP-induced aggregation of human platelet rich plasma | ChEMBL. | No reference |
IC50 (functional) | = 17 uM | Inhibition of ADP-induced aggregation of human platelet rich plasma | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.