Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2362 | 0.5668 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0372 | 0.0161 |
Brugia malayi | hypoxia-induced factor 1 | 0.0148 | 0.2058 | 0.5141 |
Brugia malayi | hypothetical protein | 0.0161 | 0.2261 | 0.5649 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0372 | 0.0161 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0372 | 0.0415 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0215 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2261 | 0.5649 |
Echinococcus granulosus | geminin | 0.0167 | 0.2362 | 0.2194 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0419 | 0.0538 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.0215 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.0215 | 0.0538 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2362 | 0.5668 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.4003 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.4003 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.4003 | 0.3871 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.2362 | 0.2194 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0419 | 0.1046 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0419 | 0.0538 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0148 | 0.2058 | 0.5141 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0372 | 0.0415 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.4003 | 0.3871 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0372 | 0.0929 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0372 | 0.0161 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.4003 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0372 | 0.0929 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0372 | 0.0415 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0372 | 0.0161 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.4003 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1000 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
IC50 (binding) | = 2000 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.