Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0513 | 0.0643 | 1 |
Onchocerca volvulus | 0.0513 | 0.0643 | 1 | |
Echinococcus granulosus | histone deacetylase 6 | 0.0057 | 0.0039 | 0.0566 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0513 | 0.0643 | 0.0641 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0057 | 0.0039 | 0.0566 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0513 | 0.0643 | 0.0641 |
Echinococcus granulosus | histone deacetylase 1 | 0.0074 | 0.0061 | 0.0914 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0057 | 0.0039 | 0.0036 |
Brugia malayi | Histone deacetylase 1 | 0.0074 | 0.0061 | 0.0914 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0513 | 0.0643 | 0.0607 |
Trypanosoma brucei | histone deacetylase, putative | 0.0057 | 0.0039 | 0.0566 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0074 | 0.0061 | 0.0914 |
Loa Loa (eye worm) | histone deacetylase | 0.0057 | 0.0039 | 0.0605 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0074 | 0.0061 | 0.0059 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0513 | 0.0643 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0074 | 0.0061 | 0.0914 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0513 | 0.0643 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.7572 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0074 | 0.0061 | 0.0059 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0074 | 0.0061 | 0.0914 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0513 | 0.0643 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0513 | 0.0643 | 0.0641 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0513 | 0.0643 | 0.0641 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0513 | 0.0643 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.7572 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0074 | 0.0061 | 0.0914 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.7572 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.7572 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0063 | 0.0047 | 0.069 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0057 | 0.0039 | 0.0566 |
Leishmania major | histone deacetylase, putative | 0.0074 | 0.0061 | 0.0369 |
Trypanosoma brucei | histone deacetylase 4 | 0.0057 | 0.0039 | 0.0566 |
Trypanosoma brucei | pteridine reductase 1 | 0.0513 | 0.0643 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0008 | 0.0123 |
Trichomonas vaginalis | hypothetical protein | 0.7572 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0513 | 0.0643 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0513 | 0.0643 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0074 | 0.0061 | 0.0952 |
Echinococcus granulosus | histone deacetylase 6 | 0.0057 | 0.0039 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0061 | 0.0952 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.7572 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0513 | 0.0643 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0003 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.0643 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0057 | 0.0039 | 0.0566 |
Giardia lamblia | Histone deacetylase | 0.0074 | 0.0061 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0057 | 0.0039 | 0.0036 |
Echinococcus granulosus | histone deacetylase | 0.0057 | 0.0039 | 0.0566 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0074 | 0.0061 | 0.0059 |
Leishmania major | oxidoreductase-like protein | 0.0513 | 0.0643 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0057 | 0.0039 | 0.0566 |
Brugia malayi | Histone deacetylase family protein | 0.0057 | 0.0039 | 0.0566 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0029 | 0.0003 | 0.0042 |
Schistosoma mansoni | dihydropteridine reductase | 0.0513 | 0.0643 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0513 | 0.0643 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0063 | 0.0047 | 0.069 |
Echinococcus granulosus | histone deacetylase 7 | 0.0057 | 0.0039 | 0.0566 |
Onchocerca volvulus | 0.0513 | 0.0643 | 1 | |
Echinococcus multilocularis | histone deacetylase | 0.0057 | 0.0039 | 0.0566 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0513 | 0.0643 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0513 | 0.0643 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0513 | 0.0643 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0057 | 0.0039 | 0.0566 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0057 | 0.0039 | 0.0605 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0063 | 0.0047 | 0.069 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0074 | 0.0061 | 0.0914 |
Echinococcus granulosus | histone deacetylase 3 | 0.0074 | 0.0061 | 0.0914 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.7572 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0057 | 0.0039 | 0.0566 |
Plasmodium falciparum | histone deacetylase 1 | 0.0074 | 0.0061 | 0.0022 |
Schistosoma mansoni | histone deacetylase | 0.0074 | 0.0061 | 0.0914 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.7572 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0074 | 0.0061 | 0.0914 |
Trypanosoma brucei | histone deacetylase 3 | 0.0057 | 0.0039 | 0.0566 |
Leishmania major | histone deacetylase, putative | 0.0074 | 0.0061 | 0.0369 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0057 | 0.0039 | 0.0566 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0513 | 0.0643 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0513 | 0.0643 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0057 | 0.0039 | 0.0566 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0513 | 0.0643 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0074 | 0.0061 | 0.0914 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0057 | 0.0039 | 0.0566 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0513 | 0.0643 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0074 | 0.0061 | 0.0914 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0057 | 0.0039 | 0.0036 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0513 | 0.0643 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0074 | 0.0061 | 0.0952 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0513 | 0.0643 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cells killed (functional) | = 2 % | Tested for percent of L1210 cells killed by dose 104 mg/kg administered intraperitoneally | ChEMBL. | 2319564 |
T/C (functional) | = 101 % | Tested for postinoculation lifespan in L1210-inoculated mice at dose 104 mg/kg administered intraperitoneally | ChEMBL. | 2319564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.