TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 552.662 | Formula: C28H28N2O6S2
H donors: 2 H acceptors: 4 LogP: 4.96 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: C=CCOc1ccc2c(c1)cc(cc2)CN(S(=O)(=O)c1ccc(cc1)OC)[C@@H](C(=O)NO)Cc1cccs1
InChi: 1S/C28H28N2O6S2/c1-3-14-36-24-9-8-21-7-6-20(16-22(21)17-24)19-30(27(28(31)29-32)18-25-5-4-15-37-25)38(33,34)26-12-10-23(35-2)11-13-26/h3-13,15-17,27,32H,1,14,18-19H2,2H3,(H,29,31)/t27-/m1/s1
InChiKey: DLRBDUYQEBDGHZ-HHHXNRCGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tolloid-like 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	bone morphogenetic protein 1b	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	IPR000859,CUB,domain-containing	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	Bone morphogenetic protein 1 homolog precursor, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Loa Loa (eye worm)	AStacin protease	Get druggable targets OG5_130155	All targets in OG5_130155
Echinococcus multilocularis	Tolloid protein 1	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	ko:K09608 tolloid-like protein 1, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	Iroquois-class homeodomain protein IRX-1, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Echinococcus granulosus	Tolloid protein 1	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	Tolloid-like protein 2 precursor, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130155	All targets in OG5_130155

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	dro:myosuppressin receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	opsin-like receptor	0.002	0.0991	0.0991
Echinococcus granulosus	somatostatin receptor	0.002	0.0991	0.0559
Echinococcus granulosus	7tm_1 domain containing protein	0.002	0.0991	0.0559
Onchocerca volvulus		0.002	0.0991	1
Brugia malayi	GnHR receptor homolog	0.002	0.0991	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Brugia malayi	hypothetical protein	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0991	0.0991
Echinococcus granulosus	orexin receptor type 2	0.002	0.0991	0.0559
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.002	0.0991	0.0559
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Brugia malayi	RE15519p	0.002	0.0991	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1652	0.1652
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0991	0.0991
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Schistosoma mansoni	growth hormone secretagogue receptor	0.002	0.0991	0.0991
Brugia malayi	Fibulin-1 precursor	0.0018	0.0458	0.462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Brugia malayi	hypothetical protein	0.002	0.0991	1
Echinococcus multilocularis	serotonin receptor	0.002	0.0991	0.0559
Echinococcus granulosus	g protein coupled receptor	0.002	0.0991	0.0559
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0991	0.0991
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0991	0.0991
Brugia malayi	hypothetical protein	0.002	0.0991	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.002	0.0991	0.0559
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Brugia malayi	AKH receptor	0.002	0.0991	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Schistosoma mansoni	biogenic amine receptor	0.002	0.0991	0.0991
Schistosoma mansoni	histamine h1 receptor	0.002	0.0991	0.0991
Echinococcus multilocularis	sex peptide receptor	0.002	0.0991	0.0559
Schistosoma mansoni	myosin xvIII	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus multilocularis	Tolloid protein 1	0.0056	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0991	0.0991
Loa Loa (eye worm)	AStacin protease	0.0035	0.4721	0.4721
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Echinococcus granulosus	neuropeptide s receptor	0.002	0.0991	0.0559
Echinococcus granulosus	neuropeptide receptor A26	0.002	0.0991	0.0559
Schistosoma mansoni	adenoreceptor	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0991	0.0559
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.002	0.0991	0.0991
Brugia malayi	Melatonin receptor type 1A	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0056	1	1
Echinococcus granulosus	g-protein coupled receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0053	0.9427	0.9427
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Onchocerca volvulus		0.002	0.0991	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Echinococcus granulosus	fmrfamide receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	G protein coupled receptor 139	0.002	0.0991	0.0559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Brugia malayi	hypothetical protein	0.002	0.0991	1
Schistosoma mansoni	amine GPCR	0.002	0.0991	0.0991
Echinococcus granulosus	tachykinin peptides receptor 99D	0.002	0.0991	0.0559
Brugia malayi	G protein-coupled receptor F59B2.13	0.002	0.0991	1
Schistosoma mansoni	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.002	0.0991	0.0991
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.002	0.0991	0.0559
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.002	0.0991	0.0991
Brugia malayi	sulfakinin receptor protein	0.002	0.0991	1
Echinococcus multilocularis	somatostatin receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0991	0.0559
Echinococcus granulosus	g protein coupled receptor	0.002	0.0991	0.0559
Onchocerca volvulus		0.002	0.0991	1
Onchocerca volvulus		0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0991	0.0559
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0458	0.462
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	neuropeptide receptor	0.002	0.0991	0.0991
Echinococcus granulosus	peptide allatostatin:somatostatin	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0991	0.0991
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Echinococcus granulosus	allatostatin A receptor	0.002	0.0991	0.0559
Echinococcus granulosus	neuropeptide FF receptor 2	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Brugia malayi	G-protein coupled receptor	0.002	0.0991	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0991	0.0559
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0018	0.0458	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0991	0.0559
Brugia malayi	Dopamine receptor protein 1	0.002	0.0991	1
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Brugia malayi	larval opioid receptor	0.002	0.0991	1
Brugia malayi	Serotonin receptor	0.002	0.0991	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.002	0.0991	0.0559
Schistosoma mansoni	opsin-like receptor	0.002	0.0991	0.0991
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0991	0.0559
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0991	0.0991
Echinococcus multilocularis	G-protein coupled receptor, putative	0.002	0.0991	0.0559
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.002	0.0991	0.0559
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0991	0.0559
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Brugia malayi	hypothetical protein	0.002	0.0991	1
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0991	0.0559
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Onchocerca volvulus		0.002	0.0991	1
Schistosoma mansoni	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0056	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0991	0.0991
Echinococcus granulosus	neuropeptide receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus granulosus	dro:myosuppressin receptor	0.002	0.0991	0.0559
Onchocerca volvulus	Neuropeptide F receptor homolog	0.002	0.0991	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0991	0.0559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Schistosoma mansoni	neuropeptide receptor	0.002	0.0991	0.0991
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0991	0.0991
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.002	0.0991	1
Echinococcus granulosus	neuropeptide receptor	0.002	0.0991	0.0559
Schistosoma mansoni	neuropeptide receptor	0.002	0.0991	0.0991
Brugia malayi	hypothetical protein	0.002	0.0991	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.002	0.0991	0.0991
Schistosoma mansoni	hypothetical protein	0.002	0.0991	0.0991
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	melatonin receptor type 1A	0.002	0.0991	0.0991
Brugia malayi	Dopamine receptor protein 2	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.002	0.0991	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0991	0.0559
Schistosoma mansoni	neuropeptide receptor	0.002	0.0991	0.0991
Schistosoma mansoni	amine GPCR	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	TYRA-2 protein	0.002	0.0991	0.0991
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0991	0.0559
Echinococcus granulosus	alpha 1A adrenergic receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Brugia malayi	putative neuropeptide receptor	0.002	0.0991	1
Onchocerca volvulus		0.002	0.0991	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0991	0.0991
Brugia malayi	Dopamine receptor	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0991	0.0559
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0991	0.0559
Echinococcus granulosus	g protein coupled receptor	0.002	0.0991	0.0559
Brugia malayi	follicle stimulating hormone receptor	0.002	0.0991	1
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0991	0.0559
Schistosoma mansoni	hypothetical protein	0.002	0.0991	0.0991
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.002	0.0991	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	amine GPCR	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus multilocularis	serotonin receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Onchocerca volvulus		0.002	0.0991	1
Onchocerca volvulus		0.002	0.0991	1
Schistosoma mansoni	biogenic amine receptor	0.002	0.0991	0.0991
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.002	0.0991	1
Brugia malayi	ORL1-like opioid receptor	0.002	0.0991	1
Echinococcus granulosus	serotonin receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0991	0.0559
Brugia malayi	hypothetical protein	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	neuropeptide s receptor	0.002	0.0991	0.0559
Brugia malayi	putative neuropeptide receptor NPR1	0.002	0.0991	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.002	0.0991	0.0991
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0991	0.0559
Brugia malayi	G protein-coupled receptor	0.002	0.0991	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0018	0.0458	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.002	0.0991	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Schistosoma mansoni	biogenic amine receptor	0.002	0.0991	0.0991
Schistosoma mansoni	amine GPCR	0.002	0.0991	0.0991
Brugia malayi	Tachykinin-like peptides receptor 99D	0.002	0.0991	1
Brugia malayi	G-protein coupled receptor	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0991	0.0559
Brugia malayi	hypothetical protein	0.002	0.0991	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.002	0.0991	0.0991
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.002	0.0991	0.0559
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	g-protein coupled receptor	0.002	0.0991	0.0559
Echinococcus granulosus	hypothetical protein	0.002	0.0991	0.0559
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.002	0.0991	0.0991
Echinococcus granulosus	G protein coupled receptor 139	0.002	0.0991	0.0559
Brugia malayi	hypothetical protein	0.002	0.0991	1
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0991	0.0559
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.002	0.0991	0.0559
Echinococcus granulosus	7TM GPCR rhodopsin	0.002	0.0991	0.0559
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0991	0.0559
Brugia malayi	Serotonin receptor	0.002	0.0991	1
Schistosoma mansoni	amine GPCR	0.002	0.0991	0.0991
Brugia malayi	neuropeptide F receptor	0.002	0.0991	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.002	0.0991	0.0559
Schistosoma mansoni	opsin-like receptor	0.002	0.0991	0.0991
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0991	0.0991
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.002	0.0991	0.0559
Echinococcus multilocularis	orexin receptor type 2	0.002	0.0991	0.0559
Echinococcus granulosus	sex peptide receptor	0.002	0.0991	0.0559
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.002	0.0991	1
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0018	0.0458	0.0458
Schistosoma mansoni	neuropeptide f receptor 76f	0.002	0.0991	0.0991
Echinococcus multilocularis	allatostatin A receptor	0.002	0.0991	0.0559
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0991	0.0559
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0991	0.0991
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0991	0.0559
Brugia malayi	neuropeptide F receptor	0.002	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0991	0.0991
Brugia malayi	hypothetical protein	0.002	0.0991	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0991	0.0559
Echinococcus multilocularis	neuropeptide receptor A26	0.002	0.0991	0.0559

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 290 nM	Inhibitory activity against procollagen C-proteinase (PCP).	ChEMBL.	11934595
IC50 (binding)	= 290 nM	Inhibitory activity against procollagen C-proteinase (PCP).	ChEMBL.	11934595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 24472