TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 696.911 | Formula: C35H52O10S2
H donors: 0 H acceptors: 2 LogP: 6.64 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: O=C1OC2OC3(C)CCC4C2(C(C1CSCCCCCSCC1C(=O)OC2C56C1CCC(C6CCC(O2)(OO5)C)C)CCC4C)OO3
InChi: 1S/C35H52O10S2/c1-20-8-10-26-22(28(36)38-30-34(26)24(20)12-14-32(3,40-30)42-44-34)18-46-16-6-5-7-17-47-19-23-27-11-9-21(2)25-13-15-33(4)41-31(39-29(23)37)35(25,27)45-43-33/h20-27,30-31H,5-19H2,1-4H3
InChiKey: IYYRWMHGTXIFHA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0246688	0.150233	0.156035
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	neuropeptide receptor A26	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	neuropeptide receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	adenylate cyclase type IX	0.012921	0.0462678	0.0462678
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0403321	0.28885	0.5
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0246688	0.150233	0.150233
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	fmrfamide receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	g-protein coupled receptor	0.0246688	0.150233	0.150233
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	neuropeptides capa receptor	0.0246688	0.150233	0.150233
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	neuropeptide Y receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0112759	0.0317089	0.0329334
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0246688	0.150233	0.156035
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0112759	0.0317089	0.0317089
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0112759	0.0317089	0.0329334
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0246688	0.150233	0.150233
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0246688	0.150233	0.156035
Brugia malayi	neuropeptide F receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0246688	0.150233	0.150233
Echinococcus granulosus	g protein coupled receptor	0.0246688	0.150233	0.150233
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Schistosoma mansoni	growth hormone secretagogue receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	dro:myosuppressin receptor	0.0246688	0.150233	0.150233
Schistosoma mansoni	opsin-like receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	neuropeptide receptor	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Schistosoma mansoni	neuropeptide receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	7tm_1 domain containing protein	0.0246688	0.150233	0.150233
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0246688	0.150233	0.156035
Echinococcus granulosus	somatostatin receptor	0.0246688	0.150233	0.150233
Brugia malayi	RE15519p	0.0246688	0.150233	0.156035
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	neuropeptide Y receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.00885099	0.0102489	0.0106447
Echinococcus multilocularis	neuropeptides capa receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	adenylate cyclase 9	0.00917637	0.0131284	0.0131284
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	PDE1B protein	0.116489	0.962817	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0246688	0.150233	0.156035
Schistosoma mansoni	amine GPCR	0.0246688	0.150233	0.156035
Echinococcus granulosus	g protein coupled receptor	0.0246688	0.150233	0.150233
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0246688	0.150233	0.156035
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0246688	0.150233	0.156035
Echinococcus granulosus	serotonin receptor	0.0246688	0.150233	0.150233
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0246688	0.150233	0.156035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	G-protein coupled receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0112759	0.0317089	1
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0403321	0.28885	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0246688	0.150233	0.150233
Brugia malayi	AKH receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0246688	0.150233	0.150233
Echinococcus multilocularis	adenylate cyclase 9	0.00917637	0.0131284	0.0136354
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	biogenic amine receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Schistosoma mansoni	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	fmrfamide receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	neuropeptide F-like receptor	0.0246688	0.150233	0.156035
Brugia malayi	Adenylyl cyclase protein	0.00917637	0.0131284	0.0136354
Onchocerca volvulus		0.0246688	0.150233	1
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.116489	0.962817	1
Brugia malayi	Dopamine receptor	0.0246688	0.150233	0.156035
Brugia malayi	GnHR receptor homolog	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0112759	0.0317089	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.116489	0.962817	1
Echinococcus multilocularis	g protein coupled receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0403321	0.28885	0.300005
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0246688	0.150233	0.156035
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	neuropeptide Y receptor	0.0246688	0.150233	0.150233
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	g protein coupled receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	neuropeptide F receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Onchocerca volvulus		0.0246688	0.150233	1
Echinococcus granulosus	fmrfamide receptor	0.0246688	0.150233	0.150233
Echinococcus granulosus	neuropeptide receptor A26	0.0246688	0.150233	0.150233
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	TYRA-2 protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Onchocerca volvulus		0.00917637	0.0131284	0.0205701
Schistosoma mansoni	amine GPCR	0.0246688	0.150233	0.156035
Schistosoma mansoni	biogenic amine receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	histamine h1 receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	g protein coupled receptor	0.0246688	0.150233	0.150233
Brugia malayi	Melatonin receptor type 1A	0.0246688	0.150233	0.156035
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0246688	0.150233	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	conserved hypothetical protein	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	adenylyl cyclase 3	0.021772	0.124597	0.129409
Echinococcus granulosus	biogenic amine 5HT receptor	0.0246688	0.150233	0.150233
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	neuropeptide s receptor	0.0246688	0.150233	0.150233
Schistosoma mansoni	biogenic amine receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	G protein coupled receptor 139	0.0246688	0.150233	0.150233
Schistosoma mansoni	opsin-like receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.00917637	0.0131284	0.0136354
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0246688	0.150233	0.156035
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0246688	0.150233	0.156035
Brugia malayi	Dopamine receptor protein 1	0.0246688	0.150233	0.156035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0246688	0.150233	0.150233
Echinococcus granulosus	sex peptide receptor	0.0246688	0.150233	0.150233
Brugia malayi	G-protein coupled receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0246688	0.150233	0.150233
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Brugia malayi	G-protein coupled receptor	0.0246688	0.150233	0.156035
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.116489	0.962817	0.962817
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0112759	0.0317089	0.0723381
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Schistosoma mansoni	amine GPCR	0.0246688	0.150233	0.156035
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0112759	0.0317089	0.0723381
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	neuropeptide receptor	0.0246688	0.150233	0.156035
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0403321	0.28885	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0246688	0.150233	0.150233
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0403321	0.28885	0.28885
Echinococcus multilocularis	g-protein coupled receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0246688	0.150233	0.150233
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0403321	0.28885	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Schistosoma mansoni	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	somatostatin receptor	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0246688	0.150233	0.156035
Echinococcus granulosus	neuropeptide receptor	0.0246688	0.150233	0.150233
Brugia malayi	follicle stimulating hormone receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0246688	0.150233	0.150233
Echinococcus granulosus	rhodopsin orphan GPCR	0.0246688	0.150233	0.150233
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	serotonin receptor	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Brugia malayi	Dopamine receptor protein 2	0.0246688	0.150233	0.156035
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.00901013	0.0116573	0.367634
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Onchocerca volvulus		0.0246688	0.150233	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.116489	0.962817	1
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0112759	0.0317089	0.0723381
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0246688	0.150233	0.150233
Echinococcus granulosus	rhodopsin orphan GPCR	0.0246688	0.150233	0.150233
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	neuropeptide FF receptor 2	0.0246688	0.150233	0.150233
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Brugia malayi	G protein-coupled receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0403321	0.28885	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	neuropeptide f receptor 76f	0.0246688	0.150233	0.156035
Echinococcus multilocularis	sex peptide receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Echinococcus multilocularis	neuropeptides capa receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Schistosoma mansoni	amine GPCR	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	melatonin receptor type 1A	0.0246688	0.150233	0.156035
Schistosoma mansoni	opsin-like receptor	0.0246688	0.150233	0.156035
Brugia malayi	G protein-coupled receptor F59B2.13	0.0246688	0.150233	0.156035
Echinococcus multilocularis	allatostatin A receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Brugia malayi	larval opioid receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	Solute carrier family 22 5	0.12069	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0246688	0.150233	0.156035
Onchocerca volvulus	Adenylate cyclase type 3 homolog	0.00917637	0.0131284	0.0205701
Echinococcus granulosus	tm gpcr rhodopsin	0.0246688	0.150233	0.150233
Schistosoma mansoni	adenoreceptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0246688	0.150233	0.150233
Echinococcus granulosus	neuropeptides capa receptor	0.0246688	0.150233	0.150233
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Echinococcus multilocularis	g protein coupled receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0246688	0.150233	0.150233
Brugia malayi	sulfakinin receptor protein	0.0246688	0.150233	0.156035
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0246688	0.150233	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0112759	0.0317089	1
Echinococcus multilocularis	adenylate cyclase type IX	0.012921	0.0462678	0.0480545
Echinococcus granulosus	orexin receptor type 2	0.0246688	0.150233	0.150233
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.00901013	0.0116573	0.367634
Brugia malayi	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	serotonin receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Echinococcus multilocularis	neuropeptide s receptor	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Onchocerca volvulus	Adenylate cyclase type 2 homolog	0.00917637	0.0131284	0.0205701
Schistosoma mansoni	myosin xvIII	0.0246688	0.150233	0.156035
Echinococcus granulosus	7TM GPCR rhodopsin	0.0246688	0.150233	0.150233
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0403321	0.28885	1
Brugia malayi	neuropeptide F receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0246688	0.150233	0.150233
Echinococcus multilocularis	dro:myosuppressin receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	neuropeptide receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035
Schistosoma mansoni	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	neuropeptide Y receptor	0.0246688	0.150233	0.150233
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0246688	0.150233	0.156035
Brugia malayi	putative neuropeptide receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	tm gpcr rhodopsin	0.0246688	0.150233	0.150233
Brugia malayi	putative neuropeptide receptor NPR1	0.0246688	0.150233	0.156035
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0246688	0.150233	0.150233
Echinococcus granulosus	neuropeptide receptor	0.0246688	0.150233	0.150233
Brugia malayi	Serotonin receptor	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	allatostatin A receptor	0.0246688	0.150233	0.150233
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0246688	0.150233	0.156035
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Schistosoma mansoni	neuropeptide receptor	0.0246688	0.150233	0.156035
Echinococcus granulosus	hypothetical protein	0.0246688	0.150233	0.150233
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0246688	0.150233	0.156035
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0403321	0.28885	0.5
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	orexin receptor type 2	0.0246688	0.150233	0.156035
Brugia malayi	ORL1-like opioid receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	amine GPCR	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Onchocerca volvulus		0.0246688	0.150233	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0246688	0.150233	0.156035
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Loa Loa (eye worm)	hypothetical protein	0.0246688	0.150233	0.156035
Echinococcus granulosus	biogenic amine 5HT receptor	0.0246688	0.150233	0.150233
Brugia malayi	Serotonin receptor	0.0246688	0.150233	0.156035
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0112759	0.0317089	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0246688	0.150233	0.156035
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0246688	0.150233	0.156035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0246688	0.150233	0.156035

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 12 nM	Antimalarial activity against Plasmodium falciparum.	ChEMBL.	11741486
EC50 (functional)	= 12 nM	Antimalarial activity against Plasmodium falciparum.	ChEMBL.	11741486

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	11741486

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 246805