Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0141 | 0.1844 | 0.1844 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0238 | 0.3545 | 0.3545 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0141 | 0.1844 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0141 | 0.1844 | 0.1844 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0166 | 0.2286 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0141 | 0.1844 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0603 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0166 | 0.2286 | 1 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0141 | 0.1844 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0353 | 0.559 | 0.559 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0141 | 0.1844 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0143 | 0.1877 | 0.1877 |
Echinococcus granulosus | lysosomal protective protein | 0.0141 | 0.1844 | 0.1844 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0141 | 0.1844 | 1 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0141 | 0.1844 | 0.8068 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0603 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0603 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0141 | 0.1844 | 1 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0127 | 0.1598 | 0.1598 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1844 | 0.8068 |
Echinococcus multilocularis | lysosomal protective protein | 0.0141 | 0.1844 | 0.1844 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0141 | 0.1844 | 1 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0127 | 0.1598 | 0.1598 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0603 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.025 | 0.3758 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0141 | 0.1844 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0143 | 0.1877 | 0.1877 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0166 | 0.2286 | 0.2286 |
Echinococcus granulosus | Ion_trans_N domain containing protein | 0.0353 | 0.559 | 0.559 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0166 | 0.2286 | 0.2286 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0166 | 0.2286 | 0.2286 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0141 | 0.1844 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.559 | 0.559 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0603 | 1 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0603 | 1 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0603 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 87 nM | Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells | ChEMBL. | 11354384 |
IC50 (binding) | = 87 nM | Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells | ChEMBL. | 11354384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.