Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative organic anion transporter | 0.0029 | 0.0225 | 0.0219 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0029 | 0.0225 | 1 |
Onchocerca volvulus | 0.0029 | 0.0225 | 0.0219 | |
Toxoplasma gondii | protease inhibitor PI2 | 0.002 | 0.0006 | 0.0253 |
Trypanosoma cruzi | MFS transporter, putative | 0.0029 | 0.0225 | 1 |
Echinococcus granulosus | follistatin | 0.002 | 0.0006 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0006 | 0.0006 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | follistatin | 0.002 | 0.0006 | 0.0253 |
Onchocerca volvulus | 0.0029 | 0.0225 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Schistosoma mansoni | agrin | 0.002 | 0.0006 | 0.0253 |
Onchocerca volvulus | 0.0029 | 0.0225 | 0.0219 | |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.002 | 0.0006 | 0.0006 |
Echinococcus granulosus | agrin | 0.002 | 0.0006 | 0.0253 |
Schistosoma mansoni | organic anion transporter | 0.0029 | 0.0225 | 1 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0029 | 0.0225 | 1 |
Onchocerca volvulus | 0.0029 | 0.0225 | 0.0219 | |
Brugia malayi | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | organic anion transporter | 0.0029 | 0.0225 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | agrin synaptic family protein | 0.002 | 0.0006 | 0.0006 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.002 | 0.0006 | 0.0006 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0029 | 0.0225 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0029 | 0.0225 | 0.0219 |
Loa Loa (eye worm) | kazal-type serine protease inhibitor domain-containing protein | 0.002 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.002 | 0.0006 | 0.0253 |
Echinococcus multilocularis | agrin | 0.002 | 0.0006 | 0.0253 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0006 | 0.0006 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.002 | 0.0006 | 0.0006 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.002 | 0.0006 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0006 | 0.0006 |
Echinococcus multilocularis | follistatin | 0.002 | 0.0006 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0225 | 0.0225 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.002 | 0.0006 | 0.0253 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0029 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Brugia malayi | SPARC precursor | 0.002 | 0.0006 | 0.0006 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0029 | 0.0225 | 0.0225 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.002 | 0.0006 | 0.0253 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0029 | 0.0225 | 0.0225 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0029 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0006 | 0.0006 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.002 | 0.0006 | 0.0006 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.002 | 0.0006 | 0.0253 |
Onchocerca volvulus | 0.0029 | 0.0225 | 0.0219 | |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.002 | 0.0006 | 0.0006 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0029 | 0.0225 | 1 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0029 | 0.0225 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against CEM tumor cell lines ; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against L1210 tumor cell lines; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity was evaluated against B16 tumor cell lines ; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity was evaluated against Molt-4 tumor cell lines | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against WIL2 tumor cell lines ; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against WI38 tumor cell lines; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against K562 tumor cell lines; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against HL-60 tumor cell lines ; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against H596 tumor cell lines ; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against H292 tumor cell lines ; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against MCF-7 tumor cell lines; Significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against A549 tumor cell lines ; significant activity | ChEMBL. | 10743954 |
Cytotoxicity (functional) | SA 0 | Cytotoxicity evaluated against NIH3T3 tumor cell lines; Significant activity | ChEMBL. | 10743954 |
IC50 (functional) | = 14.5 uM | In vitro test for antitumor activity against human Jurkat cell line using a formazan dye (MTT) conversion assay. | ChEMBL. | 10743954 |
IC50 (functional) | = 14.5 uM | In vitro test for antitumor activity against human Jurkat cell line using a formazan dye (MTT) conversion assay. | ChEMBL. | 10743954 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10743954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.