Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0117 | 0.403 | 0.403 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1241 | 0.282 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0075 | 0.2476 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0013 | 0.0146 | 0.0203 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0013 | 0.0146 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0075 | 0.2476 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0075 | 0.2476 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0039 | 0.1118 | 0.1558 |
Giardia lamblia | Telomerase catalytic subunit | 0.0075 | 0.2476 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0013 | 0.0146 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0075 | 0.2476 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.4347 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0013 | 0.0146 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0075 | 0.2476 | 0.5547 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0013 | 0.0146 | 1 |
Brugia malayi | GGL domain containing protein | 0.0117 | 0.403 | 0.5618 |
Brugia malayi | PAS domain containing protein | 0.0013 | 0.0123 | 0.0172 |
Mycobacterium ulcerans | putative regulatory protein | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | GGL domain-containing protein | 0.0117 | 0.403 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0013 | 0.0146 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0075 | 0.2476 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0075 | 0.2476 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0013 | 0.0146 | 0.0053 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0013 | 0.0146 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0013 | 0.0146 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.02 | 0.7173 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0039 | 0.1118 | 0.2502 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0013 | 0.0146 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.4347 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1241 | 0.173 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CIC95 (functional) | = 25 uM | In vitro inhibition of (HIV-1 IIIB) replication. | ChEMBL. | 11150161 |
IC50 (binding) | = 0.5 uM | Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay. | ChEMBL. | 11150161 |
IC50 (binding) | = 0.5 uM | Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay. | ChEMBL. | 11150161 |
IC50 (binding) | = 1 uM | Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay. | ChEMBL. | 11150161 |
IC50 (binding) | = 1 uM | Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay. | ChEMBL. | 11150161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.