Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | 0.0484 | 0.3629 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0477 | 0.3546 | 0.4561 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.3546 | 0.2068 |
Schistosoma mansoni | integrin alpha | 0.0631 | 0.5548 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0484 | 0.3629 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0348 | 0.1866 | 0.0004 |
Echinococcus multilocularis | integrin alpha ps | 0.0283 | 0.1013 | 0.1099 |
Echinococcus granulosus | integrin alpha ps | 0.0283 | 0.1013 | 0.1099 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0631 | 0.5548 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0283 | 0.1013 | 0.1099 |
Schistosoma mansoni | integrin alpha-ps | 0.0283 | 0.1013 | 0.1825 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 0.3781 | 0.2358 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative potency (functional) | = 19 | Effect of the compound on serum VLDL+LDL cholesterol (relative to cholestipol hydrochloride) at a doses of 25,50 mg/kg BW per day | ChEMBL. | 1560437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.