Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0787 | 0.9749 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9524 | 0.977 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0787 | 0.9749 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 26 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8978832 |
EC50 (binding) | = 26 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8978832 |
Eff (binding) | = 47 % | Relative efficacy for Retinoic acid receptor beta compared to maximal retinoic acid response | ChEMBL. | 8978832 |
Eff (binding) | = 47 % | Relative efficacy for Retinoic acid receptor beta compared to maximal retinoic acid response | ChEMBL. | 8978832 |
Kd (binding) | = 189 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR beta | ChEMBL. | 8978832 |
Kd (binding) | = 189 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR beta | ChEMBL. | 8978832 |
Kd (binding) | = 303 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR alpha | ChEMBL. | 8978832 |
Kd (binding) | = 303 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR alpha | ChEMBL. | 8978832 |
Kd (binding) | = 1490 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR gamma | ChEMBL. | 8978832 |
Kd (binding) | = 1490 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR gamma | ChEMBL. | 8978832 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.