Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.0567 | 0.2728 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0567 | 0.2728 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0567 | 0.2728 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0567 | 0.2728 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0567 | 0.2728 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0567 | 0.2728 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0567 | 0.2728 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0811 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0811 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0567 | 0.2728 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0567 | 0.2728 | 1 |
Onchocerca volvulus | 0.0475 | 0 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0811 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0811 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0567 | 0.2728 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0811 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.018 uM | Concentration required to inhibit PAF-induced maximum platelet aggregation in rabbit platelet-rich plasma | ChEMBL. | 8558517 |
ID50 (functional) | = 0.0079 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through intravenous route | ChEMBL. | 8558517 |
ID50 (functional) | = 0.0079 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through intravenous route | ChEMBL. | 8558517 |
ID50 (functional) | = 0.022 mg kg-1 | Dose required to reduce the lowering of the arterial blood pressure caused by PAF by 50% after intravenous administration in rats | ChEMBL. | 8558517 |
ID50 (functional) | > 1 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through oral administration | ChEMBL. | 8558517 |
ID50 (functional) | > 1 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through oral administration | ChEMBL. | 8558517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.