Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0121 | 0.4488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0246 | 0.0246 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Cation transporter family protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0038 | 0.0246 | 0.0547 |
Onchocerca volvulus | 0.0038 | 0.0246 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0121 | 0.4488 | 1 |
Onchocerca volvulus | 0.0038 | 0.0246 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0061 | 0.1449 | 0.3229 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0038 | 0.0246 | 0.0246 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0121 | 0.4488 | 0.4488 |
Brugia malayi | Cation transporter family protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.4488 | 1 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0121 | 0.4488 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0246 | 0.0246 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | LGC-31 protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0038 | 0.0246 | 0.0547 |
Onchocerca volvulus | 0.0038 | 0.0246 | 0.5 | |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0121 | 0.4488 | 0.4488 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0038 | 0.0246 | 0.0246 |
Onchocerca volvulus | 0.0038 | 0.0246 | 0.5 | |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0059 | 0.1357 | 0.3024 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0246 | 0.0246 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0038 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Onchocerca volvulus | 0.0038 | 0.0246 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Cation transporter family protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.4488 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0778 | 0.1734 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | ACC-1 protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | ACC-1 protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0038 | 0.0246 | 0.0547 |
Onchocerca volvulus | Putative nachr subunit | 0.0038 | 0.0246 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0778 | 0.1734 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0121 | 0.4488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0246 | 0.0547 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0778 | 0.1734 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0778 | 0.1734 |
Onchocerca volvulus | 0.0038 | 0.0246 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0038 | 0.0246 | 0.0246 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0038 | 0.0246 | 0.0246 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0246 | 0.0547 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0246 | 0.0246 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0038 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0246 | 0.0547 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Minimal bacteriostatic concentration (functional) | 0 | Minimal bacteriostatic concentration against streptococcus pyogenes under conditions of pH 7.3, 37 degree C; 1 in 5000 | ChEMBL. | 6979630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.