Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dual oxidase homolog | 0.0521 | 0.7459 | 1 |
Schistosoma mansoni | peroxidasin | 0.0521 | 0.7459 | 0.7459 |
Onchocerca volvulus | Peroxidasin homolog | 0.0521 | 0.7459 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Onchocerca volvulus | 0.0521 | 0.7459 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Onchocerca volvulus | 0.0521 | 0.7459 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0521 | 0.7459 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0521 | 0.7459 | 1 |
Schistosoma mansoni | peroxidasin | 0.0521 | 0.7459 | 0.7459 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0521 | 0.7459 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0521 | 0.7459 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0521 | 0.7459 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0521 | 0.7459 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0661 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Onchocerca volvulus | 0.0521 | 0.7459 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0521 | 0.7459 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Echinococcus granulosus | peroxidasin | 0.0521 | 0.7459 | 0.7459 |
Brugia malayi | Animal haem peroxidase family protein | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0462 | 0.6387 | 0.6387 |
Brugia malayi | hypothetical protein | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0521 | 0.7459 | 0.7459 |
Schistosoma mansoni | lipoxygenase | 0.0661 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Brugia malayi | Peroxidasin | 0.0521 | 0.7459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.7459 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0521 | 0.7459 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0521 | 0.7459 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = -9.52 | in vitro agonist activity against peroxisome proliferator activated receptor-gamma (PPAR-gamma), using alkaline phosphatase activity transactivator assay | ChEMBL. | 9836622 |
EC50 (functional) | = -7.89 | -log concentration required to induce 50% maximum lipogenic activity against Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836622 |
Ki (binding) | = -8.62 | Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) | ChEMBL. | 9836622 |
Log EC50 (functional) | = 7.89 | -log concentration required to induce 50% maximum lipogenic activity against Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836622 |
Log EC50 (functional) | = 9.52 | in vitro agonist activity against peroxisome proliferator activated receptor-gamma (PPAR-gamma), using alkaline phosphatase activity transactivator assay | ChEMBL. | 9836622 |
Log Ki (binding) | = 8.62 | Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) | ChEMBL. | 9836622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.