Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | D-aspartate oxidase | Starlite/ChEMBL | References |
Sus scrofa | D-amino-acid oxidase | Starlite/ChEMBL | References |
Rattus norvegicus | D-amino-acid oxidase | Starlite/ChEMBL | References |
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 346 aa | 382 aa | 24.1 % |
Onchocerca volvulus | Unconventional prefoldin RPB5 interactor 1 homolog | D-amino-acid oxidase | 346 aa | 350 aa | 31.1 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-aspartate oxidase | 369 aa | 373 aa | 28.7 % |
Candida albicans | similar to putative d-amino acid oxidase | D-amino-acid oxidase | 346 aa | 388 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0714 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0779 | 1 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0779 | 1 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0779 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 115 uM | Cytotoxicity against human MT4 cells | ChEMBL. | 22607675 |
IC50 (binding) | = 4 nM | Inhibition of human recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | ChEMBL. | 19438227 |
IC50 (binding) | = 6.9 nM | Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
IC50 (binding) | = 42 nM | Inhibition of DAAO (unknown origin) by cell based assay | ChEMBL. | 23566269 |
IC50 (binding) | = 43 nM | Inhibition of human recombinant DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysis | ChEMBL. | 27089209 |
IC50 (binding) | = 94 nM | Inhibition of rat spinal DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysis | ChEMBL. | 27089209 |
IC50 (binding) | = 215 nM | Inhibition of rat recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | ChEMBL. | 19438227 |
IC50 (binding) | = 855 nM | Inhibition of human recombinant DDO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | ChEMBL. | 19438227 |
IC50 (binding) | = 0.1 uM | Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reader analysis | ChEMBL. | 27089209 |
IC50 (binding) | > 100 uM | Inhibition of HIV1 reverse transcriptase RNase H activity | ChEMBL. | 22607675 |
Inhibition (binding) | = 29 % | Displacement of [3H]-glycine from NMDA receptor of rat cortical membranes | ChEMBL. | No reference |
Inhibition (binding) | = 29 % | Displacement of [3H]-glycine from NMDA receptor of rat cortical membranes | ChEMBL. | No reference |
Inhibition (binding) | = 97 % | Inhibition of HIV1 reverse transcriptase RNase H activity assessed as remaining activity at 100 uM | ChEMBL. | 22607675 |
Kd (binding) | = 13 nM | Binding affinity to biotinylated human recombinant DAAO by Biacore assay | ChEMBL. | 19438227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.