Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0124 | 0.2557 | 0.2557 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0396 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol-4,5-bisphosphate 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0124 | 0.2557 | 0.2517 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.0124 | 0.2557 | 0.2517 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0774 | 0.0642 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0124 | 0.2557 | 0.2451 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0774 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0378 | 0.0378 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2451 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2557 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0671 | 0.0538 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0041 | 0.0531 | 0.0396 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0774 | 0.0642 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0124 | 0.2557 | 0.2451 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0303 | 0.6965 | 0.5922 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0124 | 0.2557 | 0.2451 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Leishmania major | prostaglandin f synthase, putative | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0531 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0671 | 0.0538 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0041 | 0.0531 | 0.0531 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0041 | 0.0531 | 0.0396 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0041 | 0.0531 | 0.0396 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0124 | 0.2557 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0531 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0124 | 0.2557 | 0.2517 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2557 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.014 | 0.014 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0427 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0427 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0124 | 0.2557 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0396 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Toxoplasma gondii | aldose reductase, putative | 0.0427 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0124 | 0.2557 | 0.2451 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0427 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0041 | 0.0531 | 0.0396 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0124 | 0.2557 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0671 | 0.0538 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.014 | 0.014 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0124 | 0.2557 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0303 | 0.6965 | 0.6922 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0041 | 0.0531 | 0.0396 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0025 | 0.014 | 0.0088 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0025 | 0.014 | 0.014 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0671 | 0.0538 |
Schistosoma mansoni | pol-related | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0427 | 1 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0124 | 0.2557 | 0.2451 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0378 | 0.0241 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0124 | 0.2557 | 0.2557 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0774 | 0.0774 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0671 | 0.0671 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0124 | 0.2557 | 0.2451 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.0041 | 0.0531 | 0.0396 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0041 | 0.0531 | 0.0531 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0671 | 0.0538 |
Schistosoma mansoni | aldo-keto reductase | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Echinococcus granulosus | aldehyde reductase | 0.0303 | 0.6965 | 0.6922 |
Giardia lamblia | Aldose reductase | 0.0427 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0124 | 0.2557 | 0.2451 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0025 | 0.014 | 0.0088 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0378 | 0.0241 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0124 | 0.2557 | 0.2451 |
Echinococcus granulosus | hypothetical protein | 0.0427 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CT50 (functional) | = 0.6 ug ml-1 | Cytotoxicity in rapidly proliferating CCRF-CEM cell lines after 72 hr exposure | ChEMBL. | 8960564 |
CT50 (functional) | = 0.6 ug ml-1 | Cytotoxicity in rapidly proliferating CCRF-CEM cell lines after 72 hr exposure | ChEMBL. | 8960564 |
IC50 (binding) | = 1.16 ng ml-1 | Inhibition of Phosphatidylinositol 3-kinase from bovine brain | ChEMBL. | 8960564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.