Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | integrin alpha 3 | 0.1662 | 0.4159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.1639 | 0.4082 | 0.4082 |
Schistosoma mansoni | integrin alpha-ps | 0.0972 | 0.1759 | 0.2973 |
Echinococcus granulosus | integrin beta 2 | 0.0955 | 0.17 | 0.4087 |
Echinococcus multilocularis | integrin alpha ps | 0.0972 | 0.1759 | 0.4231 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.2167 | 0.5918 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1702 | 0.4298 | 0.4298 |
Schistosoma mansoni | integrin alpha | 0.2167 | 0.5918 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.1288 | 0.2861 | 0.2861 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1639 | 0.4082 | 0.3993 |
Echinococcus multilocularis | integrin alpha 3 | 0.1662 | 0.4159 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0955 | 0.17 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.1196 | 0.2539 | 0.2539 |
Echinococcus multilocularis | integrin alpha ps | 0.0972 | 0.1759 | 0.4231 |
Echinococcus granulosus | integrin alpha ps | 0.0972 | 0.1759 | 0.4231 |
Schistosoma mansoni | integrin beta subunit | 0.0759 | 0.1019 | 0.1722 |
Schistosoma mansoni | integrin alpha-ps | 0.0506 | 0.014 | 0.0236 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 69 | Ratio of maximum plasma concentration (C) measured ex vivo to that of IC50 of (10a or 10c) in rat treated intravenously with 10 mg/kg | ChEMBL. | 8120868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.