Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0774 | 0.0642 |
Mycobacterium ulcerans | oxidoreductase | 0.0427 | 1 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.0124 | 0.2557 | 0.2517 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0041 | 0.0531 | 0.0396 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0378 | 0.0241 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0774 | 0.0774 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0671 | 0.0538 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0427 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0378 | 0.0378 |
Brugia malayi | NADH-dependent xylose reductase | 0.0124 | 0.2557 | 0.2451 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0671 | 0.0538 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0303 | 0.6965 | 0.6922 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0671 | 0.0671 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0124 | 0.2557 | 0.2451 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0124 | 0.2557 | 0.2557 |
Leishmania major | prostaglandin f synthase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0041 | 0.0531 | 0.0531 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.014 | 0.014 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0041 | 0.0531 | 0.0396 |
Echinococcus granulosus | hypothetical protein | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0124 | 0.2557 | 0.2451 |
Schistosoma mansoni | pol-related | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.0041 | 0.0531 | 0.0396 |
Plasmodium vivax | aldehyde reductase, putative | 0.0124 | 0.2557 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0671 | 0.0538 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0124 | 0.2557 | 0.2517 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0124 | 0.2557 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0124 | 0.2557 | 0.2451 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0378 | 0.0241 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0124 | 0.2557 | 0.2557 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.014 | 0.014 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2557 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0427 | 1 | 1 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0531 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0025 | 0.014 | 0.014 |
Trypanosoma brucei | prostaglandin f synthase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0041 | 0.0531 | 0.0531 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0671 | 0.0538 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0025 | 0.014 | 0.014 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0025 | 0.014 | 0.0088 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0396 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0303 | 0.6965 | 0.5922 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0041 | 0.0531 | 0.0396 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0124 | 0.2557 | 0.2451 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0396 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2557 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0124 | 0.2557 | 1 |
Giardia lamblia | Aldose reductase | 0.0427 | 1 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0124 | 0.2557 | 0.2451 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol-4,5-bisphosphate 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0124 | 0.2557 | 0.2517 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0774 | 0.0774 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0041 | 0.0531 | 0.0396 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0774 | 0.0642 |
Trypanosoma cruzi | aldo-keto reductase | 0.0427 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0671 | 0.0538 |
Schistosoma mansoni | potassium channel beta | 0.0124 | 0.2557 | 0.2451 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0025 | 0.014 | 0.0088 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2451 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0531 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0124 | 0.2557 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0041 | 0.0531 | 0.0396 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0124 | 0.2557 | 0.2451 |
Echinococcus multilocularis | aldehyde reductase | 0.0303 | 0.6965 | 0.6922 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0025 | 0.014 | 0.014 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CT50 (functional) | = 0.2 ug ml-1 | Cytotoxicity in rapidly proliferating CCRF-CEM cell lines after 72 hr exposure | ChEMBL. | 8960564 |
CT50 (functional) | = 0.2 ug ml-1 | Cytotoxicity in rapidly proliferating CCRF-CEM cell lines after 72 hr exposure | ChEMBL. | 8960564 |
IC50 (binding) | = 0.6 ng ml-1 | Inhibition of Phosphatidylinositol 3-kinase from bovine brain | ChEMBL. | 8960564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.