Detailed information for compound 254797

Basic information

Technical information
  • TDR Targets ID: 254797
  • Name: 2-(2,6-dichlorophenyl)-5,6-dihydroimidazo[2,1 -b][1,3]thiazole
  • MW: 271.166 | Formula: C11H8Cl2N2S
  • H donors: 0 H acceptors: 0 LogP: 3.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1c1sc2=NCCn2c1)Cl
  • InChi: 1S/C11H8Cl2N2S/c12-7-2-1-3-8(13)10(7)9-6-15-5-4-14-11(15)16-9/h1-3,6H,4-5H2
  • InChiKey: CILQOBXEGCOMBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,6-dichlorophenyl)-5,6-dihydroimidazo[2,1-b]thiazole
  • compound 44-549
  • 56987-45-2
  • 2-(2,6-Dichlorophenyl)-5,6-dihydroimidazo(2,1-b)thiazole fumarate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Matrilysin homolog 0.066 0.2268 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0362 0.0406 0.5
Loa Loa (eye worm) hypothetical protein 0.0611 0.1964 0.1964
Onchocerca volvulus 0.0422 0.0778 0.3431
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.055 0.1578 0.5978
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1082 0.4908 0.3663
Toxoplasma gondii calcium binding egf domain-containing protein 0.0611 0.1964 0.5
Loa Loa (eye worm) hypothetical protein 0.0362 0.0406 0.0406
Brugia malayi Fibulin-1 precursor 0.0611 0.1964 0.7438
Brugia malayi Hemopexin family protein 0.0422 0.0778 0.2947
Loa Loa (eye worm) matrixin family protein 0.072 0.264 0.264
Mycobacterium leprae PROBABLE HYDROLASE 0.0362 0.0406 0.5
Loa Loa (eye worm) hypothetical protein 0.055 0.1578 0.1578
Loa Loa (eye worm) hypothetical protein 0.055 0.1578 0.1578
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.055 0.1578 0.1578
Schistosoma mansoni hypothetical protein 0.0422 0.0778 0.0778
Loa Loa (eye worm) bone morphogenetic protein 1b 0.1896 1 1
Schistosoma mansoni egf-like domain protein 0.055 0.1578 0.1578
Mycobacterium ulcerans hydrolase 0.0362 0.0406 0.5
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.1896 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0611 0.1964 0.7438
Onchocerca volvulus Arrow homolog 0.055 0.1578 0.696
Loa Loa (eye worm) matrixin family protein 0.066 0.2268 0.2268
Loa Loa (eye worm) AStacin protease 0.1185 0.5554 0.5554
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0362 0.0406 0.1537
Toxoplasma gondii calcium binding egf domain-containing protein 0.0611 0.1964 0.5
Onchocerca volvulus Matrix metalloproteinase homolog 0.066 0.2268 1
Brugia malayi Matrixin family protein 0.072 0.264 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0611 0.1964 0.1964
Loa Loa (eye worm) hypothetical protein 0.1819 0.9518 0.9518
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1082 0.4908 0.3663
Loa Loa (eye worm) hypothetical protein 0.0772 0.2969 0.2969
Echinococcus multilocularis Tolloid protein 1 0.1896 1 1

Activities

Activity type Activity value Assay description Source Reference
logD (ADMET) = 2.02 Partition coefficient (logD7.4) ChEMBL. 6264080
pC25 (functional) = 2.77 Central hypotensive activity in anesthetized normotensive rats. ChEMBL. 6264080
pC60 (functional) = 2.4 Peripheral hypertensive activity in pithed normotensive rats. ChEMBL. 6264080

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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