Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.00633241 | 0.0265993 | 0.0265993 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0394 | 0.4475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00633241 | 0.0265993 | 0.0265993 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2275 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.00633241 | 0.0265993 | 0.0265993 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4475 | 0.299 |
Mycobacterium leprae | probable zinc metalloprotease | 0.00769867 | 0.0502169 | 0.5 |
Toxoplasma gondii | peptidase family M13 protein | 0.00769867 | 0.0502169 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2275 | 0.0199 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.00769867 | 0.0502169 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0394 | 0.4475 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2275 | 0.0199 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.00769867 | 0.0502169 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00615993 | 0.0236176 | 0.0236176 |
Loa Loa (eye worm) | hypothetical protein | 0.00633241 | 0.0265993 | 0.0265993 |
Loa Loa (eye worm) | hypothetical protein | 0.00615993 | 0.0236176 | 0.0236176 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0635 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00633241 | 0.0265993 | 0.0265993 |
Loa Loa (eye worm) | hypothetical protein | 0.00633241 | 0.0265993 | 0.0265993 |
Loa Loa (eye worm) | hypothetical protein | 0.00769867 | 0.0502169 | 0.0502169 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0626427 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.00615993 | 0.0236176 | 0.0236176 |
Onchocerca volvulus | 0.00479367 | 0 | 0.5 | |
Mycobacterium ulcerans | zinc metalloprotease | 0.00769867 | 0.0502169 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00769867 | 0.0502169 | 0.0502169 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.00769867 | 0.0502169 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0394 | 0.4475 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00615993 | 0.0236176 | 0.0236176 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0394 | 0.4475 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.00769867 | 0.0502169 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.00615993 | 0.0236176 | 0.0236176 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2275 | 0.0199 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0394 | 0.4475 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2275 | 0.0199 |
Toxoplasma gondii | peptidase family M13 protein | 0.0394 | 0.4475 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2275 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.00769867 | 0.0502169 | 0.0502169 |
Loa Loa (eye worm) | hypothetical protein | 0.00615993 | 0.0236176 | 0.0236176 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0626427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4475 | 0.299 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4475 | 0.299 |
Mycobacterium tuberculosis | Possible exported protein | 0.0519 | 0.7333 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.98 uM | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum clone, CDC/Sierra Leone I (strain D6) | ChEMBL. | 8544179 |
IC50 (functional) | = 0.98 uM | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum clone, CDC/Sierra Leone I (strain D6) | ChEMBL. | 8544179 |
IC50 (functional) | = 1 uM | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum clone, CDC/Indochina III (strain W2) | ChEMBL. | 8544179 |
IC50 (functional) | = 1 uM | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum clone, CDC/Indochina III (strain W2) | ChEMBL. | 8544179 |
Resistance index (functional) | = 1 | Ratio of IC50 of W2 strain to D6 strain. | ChEMBL. | 8544179 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 8544179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.