Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.052 | 1 | 0.5 |
Onchocerca volvulus | 0.052 | 1 | 0.5 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.052 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0248 | 0.3517 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.052 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.052 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.052 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.052 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.052 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.052 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.052 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.052 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.052 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.052 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.1018 | 0.1018 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.052 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.8 nM | In vitro inhibition of LTB4 formation in human peripheral blood polymorphonuclear leukocytes (HPMN) | ChEMBL. | 8120869 |
IC50 (functional) | = 4.8 nM | In vitro inhibition of LTB4 formation in human peripheral blood polymorphonuclear leukocytes (HPMN) | ChEMBL. | 8120869 |
IC50 (binding) | = 160 nM | In vitro potency against human 5-Lipoxygenase | ChEMBL. | 8120869 |
IC50 (binding) | = 160 nM | In vitro potency against human 5-Lipoxygenase | ChEMBL. | 8120869 |
IC50 (functional) | = 1400 nM | In vitro inhibition of LTB4 formation in human whole blood(HWB) | ChEMBL. | 8120869 |
IC50 (functional) | = 1400 nM | In vitro inhibition of LTB4 formation in human whole blood(HWB) | ChEMBL. | 8120869 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8120869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.