Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Treponema pallidum | adenylate kinase (adk) | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Schistosoma mansoni | dihydrofolate reductase | 0.0478 | 0.4801 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0439 | 0.4375 | 0.4375 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0951 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0238 | 0.2162 | 0.3423 |
Schistosoma mansoni | adenylate kinase | 0.011 | 0.0749 | 0.156 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0481 | 0.4832 | 1 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Echinococcus multilocularis | thymidylate synthase | 0.0238 | 0.2162 | 0.2162 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0478 | 0.4801 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0478 | 0.4801 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0478 | 0.4801 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0478 | 0.4801 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0478 | 0.4801 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0238 | 0.2162 | 0.2162 |
Brugia malayi | dihydrofolate reductase family protein | 0.0478 | 0.4801 | 1 |
Onchocerca volvulus | 0.0238 | 0.2162 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Schistosoma mansoni | ATP-diphosphohydrolase 1 | 0.0352 | 0.3416 | 0.7115 |
Plasmodium falciparum | apyrase, putative | 0.0352 | 0.3416 | 0.7069 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0478 | 0.4801 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0113 | 0.0789 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0478 | 0.4801 | 0.4801 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0113 | 0.0789 | 0.1633 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0439 | 0.4375 | 0.4375 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0238 | 0.2162 | 0.4504 |
Echinococcus granulosus | dihydrofolate reductase | 0.0478 | 0.4801 | 0.4801 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0238 | 0.2162 | 0.3423 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0439 | 0.4375 | 0.9113 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 0.9 | In vitro antimycotic activity of compound against C. albicans was determined as -log MIC90 compound to that of -log MIC90 bifonazole | ChEMBL. | 8632429 |
Ratio (functional) | = 7.8 | Ratio of the in vitro minimal inhibitory to that of bifonazole against Candida albicans (MICcompd/MICbifonazole) | ChEMBL. | 16078834 |
Ratio (functional) | = 0.9 | In vitro antimycotic activity of compound against C. albicans was determined as -log MIC90 compound to that of -log MIC90 bifonazole | ChEMBL. | 8632429 |
Ratio (functional) | = 7.2 | Anticandida activity- (MIC90 compound) / (MIC90 bifonazole) | ChEMBL. | 12061875 |
Ratio (functional) | = 7.8 | Ratio of the in vitro minimal inhibitory to that of bifonazole against Candida albicans (MICcompd/MICbifonazole) | ChEMBL. | 16078834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.