Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase A2, group IIA (platelets, synovial fluid) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Phospholipase A2 family protein | phospholipase A2, group IIA (platelets, synovial fluid) | 144 aa | 125 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0074 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0074 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0182 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0074 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.344 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0074 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182 | 1 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0182 | 1 | 0.5 |
Brugia malayi | Phospholipase A2 family protein | 0.0111 | 0.344 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0182 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.344 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0074 | 0 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0111 | 0.344 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0111 | 0.344 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0074 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 3 uM | Effective dose of compound against contraction of Guinea pig lung tissue with arachidonic acid. | ChEMBL. | 8978843 |
IC50 (binding) | = 0.024 uM | Inhibition of human non-pancreatic secretory phospholipase A2 (PLA2) in a chromogenic assay | ChEMBL. | 8978843 |
IC50 (binding) | = 0.024 uM | Inhibition of human non-pancreatic secretory phospholipase A2 (PLA2) in a chromogenic assay | ChEMBL. | 8978843 |
IC50 (binding) | = 0.13 uM | Inhibitory activity against porcine pancreatic Phospholipase A2 | ChEMBL. | 8978843 |
IC50 (binding) | = 0.13 uM | Inhibitory activity against porcine pancreatic Phospholipase A2 | ChEMBL. | 8978843 |
IC50 (binding) | = 1.8 uM | Inhibitory activity against human pancreatic Phospholipase A2 | ChEMBL. | 8978843 |
IC50 (binding) | = 1.8 uM | Inhibitory activity against human pancreatic Phospholipase A2 | ChEMBL. | 8978843 |
KB app (functional) | = 0.2 uM | Inhibitory activity against contraction of Guinea pig lung tissue induced by PLA2. | ChEMBL. | 8978843 |
KB app (functional) | = 0.2 uM | Inhibitory activity against contraction of Guinea pig lung tissue induced by PLA2. | ChEMBL. | 8978843 |
Mole fraction (functional) | = 2 | Mole fraction is the IC50 concentration divided by total lipid concentration | ChEMBL. | 8978843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.