Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.1556 | 0.1861 | 0.214 |
Onchocerca volvulus | Matrilysin homolog | 0.3701 | 0.5112 | 1 |
Schistosoma mansoni | hypothetical protein | 0.2366 | 0.3088 | 0.6866 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.2032 | 0.2583 | 0.4597 |
Onchocerca volvulus | 0.2366 | 0.3088 | 0.3431 | |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.6066 | 0.8699 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.4034 | 0.5618 | 0.5618 |
Brugia malayi | Matrixin family protein | 0.1668 | 0.2031 | 0.3616 |
Loa Loa (eye worm) | hypothetical protein | 0.1668 | 0.2031 | 0.2031 |
Loa Loa (eye worm) | hypothetical protein | 0.1668 | 0.2031 | 0.2031 |
Echinococcus multilocularis | adam | 0.0573 | 0.037 | 0.0426 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.3295 | 0.4498 | 1 |
Mycobacterium ulcerans | hydrolase | 0.2032 | 0.2583 | 0.5 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.1556 | 0.1861 | 0.3313 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1668 | 0.2031 | 0.4516 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.2032 | 0.2583 | 0.5 |
Brugia malayi | Matrixin family protein | 0.1668 | 0.2031 | 0.3616 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.2032 | 0.2583 | 0.5 |
Brugia malayi | Matrixin family protein | 0.4034 | 0.5618 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.2068 | 0.2637 | 0.3031 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0573 | 0.037 | 0.0824 |
Echinococcus granulosus | adam 17 protease | 0.3624 | 0.4996 | 0.5743 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1668 | 0.2031 | 0.2031 |
Brugia malayi | Matrixin family protein | 0.1668 | 0.2031 | 0.3616 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.1556 | 0.1861 | 0.4138 |
Echinococcus granulosus | adam | 0.0573 | 0.037 | 0.0426 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.3701 | 0.5112 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.6066 | 0.8699 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.3295 | 0.4498 | 0.5171 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.1556 | 0.1861 | 0.214 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.2068 | 0.2637 | 0.3031 |
Loa Loa (eye worm) | hypothetical protein | 0.2032 | 0.2583 | 0.2583 |
Loa Loa (eye worm) | hypothetical protein | 0.1668 | 0.2031 | 0.2031 |
Loa Loa (eye worm) | matrixin family protein | 0.3701 | 0.5112 | 0.5112 |
Brugia malayi | Matrixin family protein | 0.1668 | 0.2031 | 0.3616 |
Brugia malayi | Hemopexin family protein | 0.2366 | 0.3088 | 0.5498 |
Brugia malayi | hypothetical protein | 0.0573 | 0.037 | 0.0659 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.1148 | 0.1242 | 0.2761 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | < 100 ug ml-1 | Antifungal activity against Trichophyton mentagrophytes. | ChEMBL. | 3510297 |
MIC (functional) | < 100 ug ml-1 | Antifungal activity against Epidermophyton floccosum. | ChEMBL. | 3510297 |
MIC (functional) | < 100 ug ml-1 | Antifungal activity against Microsporum canis | ChEMBL. | 3510297 |
MIC (functional) | < 100 ug ml-1 | Antifungal activity measured against Aspergillus fumigatus | ChEMBL. | 3510297 |
MIC (functional) | < 100 ug ml-1 | Antifungal activity measured against Sporothrix schenck ii. | ChEMBL. | 3510297 |
MIC (functional) | < 100 ug ml-1 | Antifungal activity against Candida parapsilosis. | ChEMBL. | 3510297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.