Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.285 | 0.673 | 0.6692 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.089 | 0.155 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.3028 | 0.7201 | 0.7168 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.3028 | 0.7201 | 0.7168 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.089 | 0.155 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0525 | 0.0586 | 0.0476 |
Chlamydia trachomatis | glutamine binding protein | 0.089 | 0.155 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.035 | 0.0122 | 0.0007 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.035 | 0.0122 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0525 | 0.0586 | 0.0476 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0525 | 0.0586 | 0.0476 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0347 | 0.0115 | 0.9448 |
Schistosoma mansoni | glutamate receptor NMDA | 0.3376 | 0.8118 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0525 | 0.0586 | 0.0476 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0382 | 0.0207 | 0.0115 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1237 | 0.2468 | 0.238 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.089 | 0.155 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.4088 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0327 | 0.0061 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.089 | 0.155 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0347 | 0.0115 | 0.9448 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0525 | 0.0586 | 0.0476 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0327 | 0.0061 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.035 | 0.0122 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.285 | 0.673 | 0.6692 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.035 | 0.0122 | 0.0007 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0525 | 0.0586 | 0.0476 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0525 | 0.0586 | 0.0476 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0382 | 0.0207 | 0.0115 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.089 | 0.155 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0525 | 0.0586 | 0.0476 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0525 | 0.0586 | 0.0476 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0525 | 0.0586 | 0.0476 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | In vitro inhibitory concentration of the compound against growth of mouse sarcoma 180 (S-180) cells; Inactive | ChEMBL. | 9046342 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.