Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Curated by TDR Targets | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Get druggable targets OG5_136350 | All targets in OG5_136350 |
Schistosoma japonicum | IPR002018,Carboxylesterase, type B,domain-containing | Get druggable targets OG5_136350 | All targets in OG5_136350 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | family S9 non-peptidase homologue (S09 family) | 319 aa | 272 aa | 39.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.0508 | 0.1373 | 0.5 |
Trypanosoma brucei | histone deacetylase 3 | 0.0544 | 0.1619 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0556 | 0.1701 | 0.0985 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0508 | 0.1373 | 0.4518 |
Loa Loa (eye worm) | hypothetical protein | 0.0753 | 0.3039 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0544 | 0.1619 | 0.749 |
Brugia malayi | Histone deacetylase family protein | 0.0544 | 0.1619 | 0.0285 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0544 | 0.1619 | 0.749 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0508 | 0.1373 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Giardia lamblia | Histone deacetylase | 0.0508 | 0.1373 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0556 | 0.1701 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0508 | 0.1373 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0544 | 0.1619 | 0.749 |
Trypanosoma brucei | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1 | 0.471 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0544 | 0.1619 | 0.5328 |
Leishmania major | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.0083 | 0.0272 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0508 | 0.1373 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0544 | 0.1619 | 0.749 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0544 | 0.1619 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0544 | 0.1619 | 0.749 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0544 | 0.1619 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0544 | 0.1619 | 0.5328 |
Entamoeba histolytica | histone deacetylase, putative | 0.0508 | 0.1373 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0544 | 0.1619 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0508 | 0.1373 | 0.4518 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0508 | 0.1373 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0556 | 0.1701 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0544 | 0.1619 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0508 | 0.1373 | 0.4518 |
Leishmania major | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0508 | 0.1373 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0544 | 0.1619 | 0.749 |
Echinococcus granulosus | histone deacetylase | 0.0544 | 0.1619 | 0.749 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0544 | 0.1619 | 0.0738 |
Trypanosoma brucei | histone deacetylase 4 | 0.0544 | 0.1619 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0508 | 0.1373 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0544 | 0.1619 | 0.749 |
Brugia malayi | Histone deacetylase family protein | 0.0544 | 0.1619 | 0.0285 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0508 | 0.1373 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0508 | 0.1373 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0544 | 0.1619 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from specific protein inhibition (ECO:0000020) | Schistosoma haematobium | 292228 | ||
Annotator: | stewac@u.washington.edu | Comment: | 2009/04/02 | References: | 11821256 14527722 |
1 literature reference was collected for this gene.