Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0261 | 0.1065 | 0.3378 | |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.1184 | 0.9616 | 0.957 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0988 | 0.7795 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0487 | 0.3152 | 0.298 |
Brugia malayi | Matrixin family protein | 0.025 | 0.0957 | 0.0957 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1184 | 0.9616 | 1 |
Brugia malayi | hypothetical protein | 0.0231 | 0.0788 | 0.0788 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0231 | 0.0788 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1225 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0487 | 0.3152 | 0.3152 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0988 | 0.7795 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0231 | 0.0788 | 0.0557 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0487 | 0.3152 | 0.2336 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0988 | 0.7795 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1225 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0988 | 0.7795 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0988 | 0.7795 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0261 | 0.1065 | 0.0841 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0988 | 0.7795 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1225 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1225 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1225 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1225 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1225 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.025 | 0.0957 | 0.0207 |
Brugia malayi | thymidylate synthase | 0.0487 | 0.3152 | 0.3152 |
Mycobacterium ulcerans | thymidylate synthase | 0.0487 | 0.3152 | 0.2336 |
Loa Loa (eye worm) | thymidylate synthase | 0.0487 | 0.3152 | 0.2584 |
Onchocerca volvulus | Matrilysin homolog | 0.0229 | 0.0766 | 0.243 |
Echinococcus granulosus | thymidylate synthase | 0.0487 | 0.3152 | 0.1306 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1225 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1225 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0229 | 0.0766 | 0.243 |
Echinococcus multilocularis | thymidylate synthase | 0.0487 | 0.3152 | 0.1306 |
Onchocerca volvulus | 0.0208 | 0.0572 | 0.1816 | |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1184 | 0.9616 | 0.957 |
Onchocerca volvulus | 0.0487 | 0.3152 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Geometric mean (functional) | = 323 M | Geometric mean of the four MIC's of different sensitive gram negative bacteria. | ChEMBL. | 3546689 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against E. coli (H) a sensitive gram-negative bacteria | ChEMBL. | 3546689 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against E. coli (EC-14) a sensitive gram-negative bacteria | ChEMBL. | 3546689 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Kleb. pneumoniae (SRL-1) a sensitive gram-negative bacteria | ChEMBL. | 3546689 |
MIC (functional) | = 200 ug ml-1 | Antibacterial activity against E. coli (NIHJ JC-2) a sensitive gram-negative bacteria | ChEMBL. | 3546689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.