Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.034 | 0.9927 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.034 | 0.9927 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.034 | 0.9927 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.034 | 0.9927 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.034 | 0.9927 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.7 uM | Inhibitory activity against toxo-plasma gondii (tg) Dihydrofolate reductase (DHFR) | ChEMBL. | 12408727 |
IC50 (binding) | = 2.7 uM | Inhibitory activity against toxo-plasma gondii (tg) Dihydrofolate reductase (DHFR) | ChEMBL. | 12408727 |
IC50 (binding) | = 3 uM | Inhibitory activity against escherichia coli (ec) Dihydrofolate reductase | ChEMBL. | 12408727 |
IC50 (binding) | = 3 uM | Inhibitory activity against escherichia coli (ec) Dihydrofolate reductase | ChEMBL. | 12408727 |
IC50 (binding) | = 14 uM | Inhibitory activity against pnuemocystis carinii Dihydrofolate reductase | ChEMBL. | 12408727 |
IC50 (binding) | = 14 uM | Inhibitory activity against pnuemocystis carinii Dihydrofolate reductase | ChEMBL. | 12408727 |
IC50 (binding) | = 22 uM | Inhibitory activity against recombinant human Dihydrofolate reductase | ChEMBL. | 12408727 |
IC50 (binding) | = 22 uM | Inhibitory activity against recombinant human Dihydrofolate reductase | ChEMBL. | 12408727 |
Ratio (functional) | = 1.48 | Selectivity ratio of the compound as the ratio of IC50 value against recombinant human (rh) DHFR to that of pnuemocystis carinii (pc ) DHFR. | ChEMBL. | 12408727 |
Ratio (functional) | = 7.3 | Selectivity ratio of the compound as the ratio of IC50 value against recombinant human (rh) DHFR to that of escherichia coli (ec) DHFR. | ChEMBL. | 12408727 |
Ratio (functional) | = 8.2 | Selectivity ratio of the compound as the ratio of IC50 value against recombinant human (rh) DHFR to that of toxo-plasma gondii (tg) DHFR. | ChEMBL. | 12408727 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.