Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0029 | 0.0657 | 0.4169 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0029 | 0.0657 | 0.0657 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0019 | 0.0179 | 0.0266 |
Brugia malayi | steroid hormone receptor | 0.0029 | 0.0657 | 0.0657 |
Echinococcus granulosus | FTZ F1 alpha | 0.0029 | 0.0657 | 0.4169 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0029 | 0.0657 | 0.4169 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0657 | 0.4169 |
Loa Loa (eye worm) | glutamate receptor | 0.0016 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0657 | 0.0657 |
Onchocerca volvulus | 0.0029 | 0.0657 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 0.0657 | 0.0974 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0029 | 0.0657 | 0.0974 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0657 | 0.4169 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0029 | 0.0657 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0029 | 0.0657 | 0.0974 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0029 | 0.0657 | 0.0657 |
Schistosoma mansoni | d-amino acid oxidase | 0.0157 | 0.6742 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0029 | 0.0657 | 0.0974 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0029 | 0.0657 | 0.4169 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0144 | 0.6119 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0029 | 0.0657 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0657 | 0.0657 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0029 | 0.0657 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.6742 | 0.6742 |
Loa Loa (eye worm) | glutamate receptor | 0.0039 | 0.1141 | 0.1141 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0029 | 0.0657 | 0.4169 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0029 | 0.0657 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | ecdysteroid receptor | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0029 | 0.0657 | 0.0657 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0657 | 0.4169 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0657 | 0.4169 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0036 | 0.0965 | 0.0965 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0029 | 0.0657 | 0.0974 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0657 | 0.0657 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0657 | 0.4169 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 0.0657 | 0.0974 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 0.0657 | 0.0974 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0657 | 0.4169 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0029 | 0.0657 | 0.4169 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0657 | 0.0657 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0029 | 0.0657 | 0.4169 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0029 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0049 | 0.1575 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0657 | 0.0657 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0029 | 0.0657 | 0.0974 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0029 | 0.0657 | 0.0974 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0033 | 0.0837 | 0.5313 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0657 | 0.0657 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0033 | 0.0837 | 0.5313 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0657 | 0.4169 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0049 | 0.1575 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0039 | 0.1141 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1575 | 0.1575 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0029 | 0.0657 | 0.0974 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0019 | 0.0179 | 0.0179 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0029 | 0.0657 | 0.0974 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0033 | 0.0837 | 0.1241 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0657 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.0657 | 0.0657 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0657 | 0.4169 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0657 | 0.4169 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0157 | 0.6742 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0029 | 0.0657 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0657 | 0.0657 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0157 | 0.6742 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0657 | 0.0657 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0045 | 0.1399 | 0.2075 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0029 | 0.0657 | 0.0974 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 22 % | Percent inhibition of SRS-A induced contraction minus percent inhibition of 25 mM KCl induced contractions at a conc of 5(microM) | ChEMBL. | 7143363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.