Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0398 | 1 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0165 | 0.0991 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0398 | 1 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.5447 | 0.5414 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.5447 | 0.5414 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0398 | 1 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0165 | 0.0991 | 0.0991 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0398 | 1 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0165 | 0.0991 | 0.0991 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.9248 | 0.9248 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0165 | 0.0991 | 0.0991 |
Trypanosoma cruzi | GMP reductase | 0.0398 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0209 | 0.2679 | 0.0954 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0398 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0398 | 1 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0374 | 0.9085 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0398 | 1 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.9248 | 0.9248 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0398 | 1 | 1 |
Brugia malayi | GMP reductase | 0.0165 | 0.0991 | 0.0991 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0205 | 0.0205 |
Toxoplasma gondii | IMP dehydrogenas | 0.0398 | 1 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.3219 | 0.1787 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0374 | 0.9085 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0374 | 0.9085 | 0.8869 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0398 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0398 | 1 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0398 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0398 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0398 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0398 | 1 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0398 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0398 | 1 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.1744 | 0.1744 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | = 30 min | Ex vivo duration of inhibition of ADP-induced canine platelet aggregation by 3 mg/kg. | ChEMBL. | 10602710 |
IC50 (binding) | = 66.8 nM | In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | ChEMBL. | 10602710 |
IC50 (binding) | = 66.8 nM | In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | ChEMBL. | 10602710 |
IC50 (functional) | = 11.8 uM | In vitro inhibitory potency against human gel filtered platelet (GFP) aggregation | ChEMBL. | 10602710 |
IC50 (functional) | = 11.8 uM | In vitro inhibitory potency against human gel filtered platelet (GFP) aggregation | ChEMBL. | 10602710 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10602710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.