Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0425 | 0.601 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0682 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0682 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0164 | 0.1964 | 0.1964 |
Echinococcus granulosus | dihydrofolate reductase | 0.0682 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0629 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.017 | 0.2058 | 0.2058 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0425 | 0.601 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0164 | 0.1964 | 0.1964 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0425 | 0.601 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.017 | 0.2058 | 0.2058 |
Schistosoma mansoni | dihydrofolate reductase | 0.0682 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0425 | 0.601 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.017 | 0.2058 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0682 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0164 | 0.1964 | 0.1425 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0682 | 1 | 1 |
Onchocerca volvulus | 0.0164 | 0.1964 | 1 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.0078 | 0.0629 | 0.0629 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0682 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0425 | 0.601 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0164 | 0.1964 | 0.1964 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0682 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0425 | 0.601 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0682 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 0 % | percent reduction in Ancylostoma eggs per gram, after oral treatment of 100 mg/dog dose of compound in a single treatment | ChEMBL. | 7241511 |
Reduction (functional) | = 0 % | Percent reduction in Uncinaria eggs per gram, after oral treatment of 100 mg/dog dose of compound in a single treatment | ChEMBL. | 7241511 |
Reduction (functional) | = 0 % | Percent reduction in Toxascaris eggs per gram, after oral treatment of 100 mg/dog dose of compound in a single treatment | ChEMBL. | 7241511 |
Reduction (functional) | 0 % | Percent reduction in Haemonchus eggs per gram, after treatment of 100 mg/kg dose of compound perorally in sheep; Toxic | ChEMBL. | 7241511 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.