Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.1017 | 0.8363 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1017 | 0.8363 | 0.8206 |
Schistosoma mansoni | dihydrofolate reductase | 0.1017 | 0.8363 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1182 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0484 | 0.3082 | 0.2418 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0905 | 0.7253 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0905 | 0.7253 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0905 | 0.7253 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1017 | 0.8363 | 0.8206 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1017 | 0.8363 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0905 | 0.7253 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0484 | 0.3082 | 0.3223 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1017 | 0.8363 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0905 | 0.7253 | 0.5 |
Onchocerca volvulus | 0.0484 | 0.3082 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.023 | 0.057 | 0.5 |
Onchocerca volvulus | 0.0261 | 0.0875 | 0.1924 | |
Brugia malayi | dihydrofolate reductase family protein | 0.1017 | 0.8363 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0905 | 0.7253 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1017 | 0.8363 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.023 | 0.057 | 0.0682 |
Mycobacterium ulcerans | thymidylate synthase | 0.0484 | 0.3082 | 0.2418 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0484 | 0.3082 | 0.3685 |
Echinococcus granulosus | dihydrofolate reductase | 0.1017 | 0.8363 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0261 | 0.0875 | 0.1047 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1017 | 0.8363 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27 uM | Inhibitory activity against human purified recombinant farnesyltransferase (hFT) | ChEMBL. | 10602709 |
IC50 (binding) | = 27 uM | Inhibitory activity against human purified recombinant farnesyltransferase (hFT) | ChEMBL. | 10602709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.