Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1375 | 0.7514 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1375 | 0.7514 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1199 | 0.6353 | 0.9545 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1752 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.09 | 0.4378 | 0.7358 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1199 | 0.6353 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1199 | 0.6353 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1199 | 0.6353 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1199 | 0.6353 | 0.9545 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1199 | 0.6353 | 0.7877 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1199 | 0.6353 | 1 |
Onchocerca volvulus | 0.0236 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.123 | 0.6558 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1199 | 0.6353 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1375 | 0.7514 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1125 | 0.5864 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1199 | 0.6353 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1199 | 0.6353 | 0.7877 |
Toxoplasma gondii | hypothetical protein | 0.0546 | 0.2046 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1752 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1199 | 0.6353 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0546 | 0.2046 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0748 | 0.3377 | 0.5578 |
Schistosoma mansoni | carbonic anhydrase | 0.1375 | 0.7514 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0236 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 15 % | In vitro average percent Inhibition of Prostaglandin G/H synthase 2 (COX-2) at a concentration of 1 microM determined in human whole blood by human whole blood (HWB) assay | ChEMBL. | 14640557 |
Inhibition (binding) | = 15 % | In vitro average percent Inhibition of Prostaglandin G/H synthase 2 (COX-2) at a concentration of 1 microM determined in human whole blood by human whole blood (HWB) assay | ChEMBL. | 14640557 |
Inhibition (binding) | = 40 % | In vitro average percent Inhibition of Prostaglandin G/H synthase 2 (COX-2) at a concentration of 10 microM determined by human whole blood (HWB) assay | ChEMBL. | 14640557 |
Inhibition (binding) | = 40 % | In vitro average percent Inhibition of Prostaglandin G/H synthase 2 (COX-2) at a concentration of 10 microM determined by human whole blood (HWB) assay | ChEMBL. | 14640557 |
Inhibition (binding) | = 70 % | In vitro average percent Inhibition of Prostaglandin G/H synthase 1 (COX-1) at a concentration of 100 microM determined in human whole blood by human whole blood (HWB) assay | ChEMBL. | 14640557 |
Inhibition (binding) | = 70 % | In vitro average percent Inhibition of Prostaglandin G/H synthase 1 (COX-1) at a concentration of 100 microM determined in human whole blood by human whole blood (HWB) assay | ChEMBL. | 14640557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.