Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2366 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2366 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2366 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2366 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1376 | 0.552 | 0.5465 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0891 | 0.3324 | 0.8602 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1218 | 0.4804 | 0.4804 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1442 | 0.5819 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1442 | 0.5819 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.2366 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2366 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.1218 | 0.4804 | 0.4623 |
Echinococcus granulosus | carbonic anhydrase | 0.1218 | 0.4804 | 0.4623 |
Schistosoma mansoni | carbonic anhydrase | 0.1218 | 0.4804 | 0.474 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1218 | 0.4804 | 0.4804 |
Echinococcus granulosus | carbonic anhydrase II | 0.2366 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2366 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1218 | 0.4804 | 0.474 |
Echinococcus multilocularis | carbonic anhydrase | 0.1218 | 0.4804 | 0.4623 |
Echinococcus granulosus | carbonic anhydrase | 0.1218 | 0.4804 | 0.4623 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1218 | 0.4804 | 0.4804 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0157 | 0 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0312 | 0.0701 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.4804 | 0.4804 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.4804 | 0.4804 |
Plasmodium falciparum | carbonic anhydrase | 0.1218 | 0.4804 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2366 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1218 | 0.4804 | 0.474 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1218 | 0.4804 | 0.4804 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1218 | 0.4804 | 0.4804 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0957 | 0.3623 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1376 | 0.552 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2366 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1218 | 0.4804 | 0.4804 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0312 | 0.0701 | 0.0701 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1442 | 0.5819 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1218 | 0.4804 | 0.4623 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1376 | 0.552 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1218 | 0.4804 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.1218 | 0.4804 | 0.4623 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2366 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1218 | 0.4804 | 0.474 |
Schistosoma mansoni | hypothetical protein | 0.1218 | 0.4804 | 0.474 |
Loa Loa (eye worm) | hypothetical protein | 0.18 | 0.7439 | 0.7439 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 27 uM | Inhibitory activity against bovine thrombin expressed as dissociation constant | ChEMBL. | 9876114 |
Ki (binding) | = 27 uM | Inhibitory activity against bovine thrombin expressed as dissociation constant | ChEMBL. | 9876114 |
Ki (binding) | = 29 uM | Inhibitory activity against bovine trypsin expressed as dissociation constant | ChEMBL. | 9876114 |
Ki (binding) | = 29 uM | Inhibitory activity against bovine trypsin expressed as dissociation constant | ChEMBL. | 9876114 |
Ki (binding) | = 230 uM | Inhibitory activity against bovine coagulation factor X expressed as dissociation constant | ChEMBL. | 9876114 |
Ki (binding) | = 230 uM | Inhibitory activity against bovine coagulation factor X expressed as dissociation constant | ChEMBL. | 9876114 |
Ki (binding) | = 800 uM | Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant | ChEMBL. | 9876114 |
Ki (binding) | = 800 uM | Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant | ChEMBL. | 9876114 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.