Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Palmitoyl-CoA oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | RING-box protein 2 homolog | Palmitoyl-CoA oxidase | 661 aa | 659 aa | 42.5 % |
Drosophila melanogaster | CG9527 gene product from transcript CG9527-RD | Palmitoyl-CoA oxidase | 661 aa | 662 aa | 32.6 % |
Dictyostelium discoideum | acyl-CoA oxidase | Palmitoyl-CoA oxidase | 661 aa | 625 aa | 28.5 % |
Drosophila melanogaster | CG4586 gene product from transcript CG4586-RA | Palmitoyl-CoA oxidase | 661 aa | 682 aa | 40.6 % |
Dictyostelium discoideum | hypothetical protein | Palmitoyl-CoA oxidase | 661 aa | 627 aa | 29.4 % |
Onchocerca volvulus | Putative cyclin-dependent kinase 9 | Palmitoyl-CoA oxidase | 661 aa | 677 aa | 26.3 % |
Dictyostelium discoideum | acyl-CoA oxidase | Palmitoyl-CoA oxidase | 661 aa | 585 aa | 29.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.065 | 0.1228 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0069 | 0.4517 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0038 | 0.065 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0038 | 0.065 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0114 | 1 | 0.5 |
Brugia malayi | Acyl-CoA oxidase family protein | 0.0053 | 0.2523 | 0.4037 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0038 | 0.065 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0076 | 0.529 | 1 |
Plasmodium vivax | transporter, putative | 0.0074 | 0.5094 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0076 | 0.529 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0074 | 0.5094 | 1 |
Brugia malayi | Hemopexin family protein | 0.0044 | 0.1423 | 0.1666 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0074 | 0.5124 | 1 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0074 | 0.5094 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0069 | 0.4517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1704 | 0.3221 |
Loa Loa (eye worm) | matrixin family protein | 0.0069 | 0.4517 | 0.8538 |
Plasmodium vivax | hypothetical protein, conserved | 0.0074 | 0.5094 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
% remaining (ADMET) | = 25 % | Metabolic stability (% remaining at 30 mins) in human S9. | ChEMBL. | 14698201 |
IC50 (binding) | = 4 uM | Inhibitory activity against Palmitoyl-CoA oxidase to inhibit rat heart mitochondrial Palmitoyl-CoA oxidation. | ChEMBL. | 14698201 |
IC50 (binding) | = 4 uM | Inhibitory activity against Palmitoyl-CoA oxidase to inhibit rat heart mitochondrial Palmitoyl-CoA oxidation. | ChEMBL. | 14698201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.