Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0082 | 0.0462 | 0.031 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0054 | 0.0157 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0203 | 0.0906 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0203 | 0.0906 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0192 | 0.1682 | 0.155 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0082 | 0.0462 | 0.031 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0082 | 0.0462 | 0.031 |
Schistosoma mansoni | glutamate receptor kainate | 0.0054 | 0.0157 | 0.0342 |
Brugia malayi | Pre-SET motif family protein | 0.0243 | 0.224 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0082 | 0.0462 | 0.069 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0082 | 0.0462 | 0.069 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0138 | 0.1087 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0054 | 0.0157 | 0.0699 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0138 | 0.1087 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0054 | 0.0157 | 0.0342 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0455 | 0.4581 | 0.4495 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0192 | 0.1682 | 0.155 |
Trichomonas vaginalis | set domain proteins, putative | 0.0276 | 0.2611 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0243 | 0.224 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0138 | 0.1087 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0192 | 0.1682 | 0.3448 |
Chlamydia trachomatis | glutamine binding protein | 0.0138 | 0.1087 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0138 | 0.1087 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0203 | 0.0906 |
Schistosoma mansoni | glutamate receptor kainate | 0.0054 | 0.0157 | 0.0342 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0054 | 0.0157 | 0.0342 |
Onchocerca volvulus | 0.0276 | 0.2611 | 0.5 | |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0082 | 0.0462 | 0.069 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0138 | 0.1087 | 0.5 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0054 | 0.0157 | 0.0342 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0082 | 0.0462 | 0.031 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0054 | 0.0157 | 0.0342 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0455 | 0.4581 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0203 | 0.0906 |
Echinococcus granulosus | glutamate receptor 2 | 0.0082 | 0.0462 | 0.069 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0054 | 0.0157 | 0.0699 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0054 | 0.0157 | 0.0699 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0455 | 0.4581 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0082 | 0.0462 | 0.069 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0082 | 0.0462 | 0.031 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0157 | 0.0342 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0082 | 0.0462 | 0.1008 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.066 ug ml-1 | Inhibitory activity against the primary liver carcinoma (PLC) cell line PLC/PRF/5 | ChEMBL. | 12459012 |
IC50 (functional) | = 0.51 ug ml-1 | Inhibitory activity against colchicine resistant parent primary liver carcinoma (PLC) cell line PLC/PRF/5 | ChEMBL. | 12459012 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.