Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0249 | 0.2197 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.0264 | 0.2376 | 1 |
Trichomonas vaginalis | cdc25c, putative | 0.0264 | 0.2376 | 1 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0264 | 0.2376 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0249 | 0.2197 | 0.1914 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0264 | 0.2376 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0249 | 0.2197 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0264 | 0.2376 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0249 | 0.2197 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0249 | 0.2197 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0249 | 0.2197 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0264 | 0.2376 | 1 |
Onchocerca volvulus | 0.0264 | 0.2376 | 0.5 | |
Schistosoma mansoni | lipoxygenase | 0.0098 | 0.0359 | 0.151 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0249 | 0.2197 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0264 | 0.2376 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0249 | 0.2197 | 0.9245 |
Onchocerca volvulus | 0.0264 | 0.2376 | 0.5 | |
Brugia malayi | Rhodanese-like domain containing protein | 0.0264 | 0.2376 | 0.21 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0264 | 0.2376 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0264 | 0.2376 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0249 | 0.2197 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0098 | 0.0359 | 0.0046 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0098 | 0.0359 | 0.0046 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0264 | 0.2376 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0161 | 0.1129 | 0.3844 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0264 | 0.2376 | 0.21 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0249 | 0.2197 | 1 |
Onchocerca volvulus | 0.0264 | 0.2376 | 0.5 | |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0249 | 0.2197 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0249 | 0.2197 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0892 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0249 | 0.2197 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0249 | 0.2197 | 0.1914 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0264 | 0.2376 | 1 |
Onchocerca volvulus | 0.0264 | 0.2376 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 1 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0264 | 0.2376 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0161 | 0.1129 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0249 | 0.2197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2376 | 0.0318 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2376 | 0.0318 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0264 | 0.2376 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.0264 | 0.2376 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.1 ug ml-1 | Antifungal activity towards Trichophyton mentagrophytes 530324 strain | ChEMBL. | 3546691 |
MIC (functional) | = 0.1 ug ml-1 | Antifungal activity towards Trichophyton interdigitale | ChEMBL. | 3546691 |
MIC (functional) | = 1.56 ug ml-1 | Antifungal activity against Aspergillus fumigatus Saito strain | ChEMBL. | 3546691 |
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans C-A-24 strain | ChEMBL. | 3546691 |
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans C-A-24 strain | ChEMBL. | 3546691 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Cryptococcus neoformans Cr-1 strain | ChEMBL. | 3546691 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Cryptococcus neoformans Cr-1 strain | ChEMBL. | 3546691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.