I50 (functional)
|
= 0.0034 ug ml-1
|
Inhibition of Angiotensin I converting enzyme in normotensive rat
|
ChEMBL.
|
2831364
|
IC50 (functional)
|
= 0.0034 ug ml-1
|
Inhibition of Angiotensin I converting enzyme in normotensive rat
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 0 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 1 ug/kg (i.v.) for 5 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 0 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 1 ug/kg (i.v.) for 10 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 0 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 1 ug/kg (i.v.) for 30 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 0 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 1 ug/kg (i.v.) for 60 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 0 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 10 ug/kg (i.v.) for 60 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 7.8 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 10 ug/kg (i.v.) for 30 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 12.5 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 30 ug/kg (i.v.) for 75 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 14.5 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 10 ug/kg (i.v.) for 10 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 15.3 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 30 ug/kg (i.v.) for 60 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 17.3 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 30 ug/kg (i.v.) for 30 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 23.5 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 10 ug/kg (i.v.) for 5 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 24.3 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 1 ug/kg (i.v.) for 1.5 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 31.5 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 30 ug/kg (i.v.) for 10 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 39.5 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 10 ug/kg (i.v.) for 1.5 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 45 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 30 ug/kg (i.v.) for 5 min
|
ChEMBL.
|
2831364
|
Inhibition over time (functional)
|
= 79.5 %
|
Inhibition of angiotensin I induced blood pressure in normotensive anesthetized rats at 30 ug/kg (i.v.) for 1.5 min
|
ChEMBL.
|
2831364
|
Time (ADMET)
|
> 1 hr
|
Time required for 100% degradation of the compound by trypsin
|
ChEMBL.
|
2831364
|
Time (ADMET)
|
= 1 hr
|
Time required for 50% degradation of the compound in rat intestinal homogenate
|
ChEMBL.
|
2831364
|
Time (ADMET)
|
= 5 hr
|
Time required for 100% degradation of the compound in rat intestinal homogenate
|
ChEMBL.
|
2831364
|
Time (ADMET)
|
= 20 hr
|
Time required for degradation of the compound by pepsin (none)
|
ChEMBL.
|
2831364
|
Time (ADMET)
|
= 22 hr
|
Time required for 50% degradation of the compound by chymotrypsin
|
ChEMBL.
|
2831364
|
Time (ADMET)
|
= 5 min
|
Time required for 50% degradation of the compound by trypsin
|
ChEMBL.
|
2831364
|