Detailed information for compound 264488

Basic information

Technical information
  • TDR Targets ID: 264488
  • Name: (3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]pi peridin-4-one
  • MW: 365.34 | Formula: C19H15N3O5
  • H donors: 1 H acceptors: 5 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1/C(=C/c2ccc(cc2)[N+](=O)[O-])/CNC/C/1=C\c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+
  • InChiKey: YUYPWAMLWZVHAE-KAVGSWPWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]piperidin-4-one
  • (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-4-piperidinone
  • (3E,5E)-3,5-bis(4-nitrobenzylidene)-4-piperidone
  • 3,5-bis[(4-nitrophenyl)methylidene]piperidin-4-one
  • 3,5-bis[(4-nitrophenyl)methylene]piperidin-4-one
  • 3,5-bis[(4-nitrophenyl)methylene]-4-piperidinone
  • 3,5-bis(4-nitrobenzylidene)-4-piperidone
  • 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (E,E)-
  • NSC685125
  • NCI60_030638
  • 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,5E)-
  • AIDS-037405
  • AIDS037405

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0289815 0.131925 0.533777
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132102 0.00739342 0.0102588
Toxoplasma gondii AGC kinase 0.0289815 0.131925 1
Giardia lamblia Hypothetical protein 0.0338941 0.170716 0.775354
Trichomonas vaginalis cyclin B3, putative 0.0338941 0.170716 0.819092
Schistosoma mansoni protein kinase 0.103546 0.720691 1
Trypanosoma cruzi cyclin 6, putative 0.0384625 0.206788 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132102 0.00739342 0.0102588
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0289815 0.131925 0.183054
Entamoeba histolytica PH domain containing protein kinase, putative 0.0289815 0.131925 0.62455
Entamoeba histolytica cyclin family protein 0.0338941 0.170716 0.819092
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0384625 0.206788 1
Schistosoma mansoni cyclins 0.0338941 0.170716 0.228968
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0289815 0.131925 0.12546
Trichomonas vaginalis cyclin B, putative 0.0384625 0.206788 1
Plasmodium falciparum protein kinase 5 0.0181268 0.0462152 0.2377
Trichomonas vaginalis CMGC family protein kinase 0.0181268 0.0462152 0.194698
Echinococcus granulosus cyclin B 0.0384625 0.206788 0.28693
Loa Loa (eye worm) hypothetical protein 0.0289815 0.131925 0.12546
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0181268 0.0462152 0.311741
Trichomonas vaginalis cyclins, putative 0.0384625 0.206788 1
Schistosoma mansoni serine/threonine protein kinase 0.0289815 0.131925 0.174586
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.103546 0.720691 1
Schistosoma mansoni cyclin B3 0.0486204 0.286996 0.391986
Echinococcus multilocularis cyclins 0.0338941 0.170716 0.236878
Schistosoma mansoni serine/threonine protein kinase 0.0289815 0.131925 0.174586
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0289815 0.131925 0.533777
Trichomonas vaginalis cyclin B, putative 0.0384625 0.206788 1
Giardia lamblia Cyclin A 0.0338941 0.170716 0.775354
Trichomonas vaginalis cyclin D, putative 0.0338941 0.170716 0.819092
Schistosoma mansoni protein kinase 0.103546 0.720691 1
Trichomonas vaginalis cyclins, putative 0.0384625 0.206788 1
Echinococcus multilocularis cyclins 0.0338941 0.170716 0.236878
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0289815 0.131925 0.183054
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132102 0.00739342 0.0102588
Echinococcus granulosus cyclin dependent kinase 0.0181268 0.0462152 0.0641262
Echinococcus granulosus cyclin B3 1 0.0338941 0.170716 0.236878
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0181268 0.0462152 0.0641262
Echinococcus granulosus cyclin dependent kinase 5 0.0181268 0.0462152 0.0641262
Giardia lamblia G2/mitotic-specific cyclin B 0.0384625 0.206788 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.138919 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0132102 0.00739342 0.0102588
Brugia malayi Protein kinase domain containing protein 0.0181268 0.0462152 0.0391109
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0486204 0.286996 0.398223
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0289815 0.131925 1
Schistosoma mansoni serine/threonine protein kinase 0.0181268 0.0462152 0.0544257
Echinococcus multilocularis cyclins 0.0338941 0.170716 0.236878
Echinococcus multilocularis cyclins 0.0338941 0.170716 0.236878
Toxoplasma gondii AGC kinase 0.0289815 0.131925 1
Onchocerca volvulus 0.0384625 0.206788 0.5
Loa Loa (eye worm) hypothetical protein 0.0384625 0.206788 0.20088
Echinococcus multilocularis cyclin dependent kinase 1 0.0181268 0.0462152 0.0641262
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0903355 0.616382 0.613525
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0289815 0.131925 0.183054
Echinococcus multilocularis cyclin dependent kinase 0.0181268 0.0462152 0.0641262
Trichomonas vaginalis cyclin D, putative 0.0338941 0.170716 0.819092
Toxoplasma gondii hypothetical protein 0.025233 0.102327 0.762321
Trichomonas vaginalis cyclin B, putative 0.0338941 0.170716 0.819092
Trichomonas vaginalis AGC family protein kinase 0.0289815 0.131925 0.62455
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0289815 0.131925 0.533777
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0289815 0.131925 0.76249
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132102 0.00739342 0.0102588
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0181268 0.0462152 0.0391109
Trichomonas vaginalis cyclins, putative 0.0338941 0.170716 0.819092
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0903355 0.616382 0.613525
Echinococcus multilocularis cyclins 0.0338941 0.170716 0.236878
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0181268 0.0462152 0.194698
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0289815 0.131925 0.533777
Echinococcus granulosus cyclin dependent kinase 1 0.0181268 0.0462152 0.0641262
Echinococcus multilocularis cyclins 0.0338941 0.170716 0.236878
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0280452 0.124532 0.172795
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0280452 0.124532 0.172795
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0289815 0.131925 0.183054
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0289815 0.131925 1
Schistosoma mansoni protein kinase 0.103546 0.720691 1
Trichomonas vaginalis cyclins, putative 0.0132295 0.00754585 0.000764479
Echinococcus granulosus cyclins 0.0338941 0.170716 0.236878
Echinococcus multilocularis cyclin dependent kinase 5 0.0181268 0.0462152 0.0641262
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0486204 0.286996 0.398223
Echinococcus multilocularis cyclin B 0.0384625 0.206788 0.28693
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.103546 0.720691 1
Trypanosoma cruzi cyclin, putative 0.0384625 0.206788 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0384625 0.206788 1
Trichomonas vaginalis CMGC family protein kinase 0.0181268 0.0462152 0.194698
Echinococcus granulosus cyclins 0.0338941 0.170716 0.236878
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0181268 0.0462152 0.194698
Schistosoma mansoni serine/threonine protein kinase 0.0289815 0.131925 0.174586
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0289815 0.131925 0.62455
Echinococcus granulosus cyclins 0.0338941 0.170716 0.236878
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132102 0.00739342 0.0102588
Trichomonas vaginalis conserved hypothetical protein 0.0338941 0.170716 0.819092
Entamoeba histolytica PH domain containing protein kinase, putative 0.0289815 0.131925 0.62455
Giardia lamblia Kinase, AGC PKA 0.0289815 0.131925 0.533777
Trichomonas vaginalis CMGC family protein kinase 0.0181268 0.0462152 0.194698
Entamoeba histolytica cell division protein kinase 2, putative 0.0181268 0.0462152 0.194698
Brugia malayi Cyclin, N-terminal domain containing protein 0.0384625 0.206788 0.20088
Brugia malayi Cyclin, N-terminal domain containing protein 0.0384625 0.206788 0.20088
Echinococcus multilocularis cyclins 0.0338941 0.170716 0.236878
Trypanosoma brucei cdc2-related kinase 1 0.0181268 0.0462152 0.194698
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0289815 0.131925 0.62455
Echinococcus granulosus cyclins 0.0338941 0.170716 0.236878
Trichomonas vaginalis cyclin A, putative 0.0384625 0.206788 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0181268 0.0462152 0.0391109
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0181268 0.0462152 0.0391109
Entamoeba histolytica cyclin family protein 0.0338941 0.170716 0.819092
Echinococcus multilocularis cyclin b3 0.0338941 0.170716 0.236878
Echinococcus multilocularis cyclin B3 1 0.0338941 0.170716 0.236878
Plasmodium falciparum cyclin 0.0338941 0.170716 1
Trypanosoma brucei mitotic cyclin 6 0.0384625 0.206788 1
Plasmodium vivax protein kinase Crk2 0.0181268 0.0462152 0.311741
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0289815 0.131925 0.62455
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0289815 0.131925 0.183054
Loa Loa (eye worm) AGC/PKA protein kinase 0.0289815 0.131925 0.12546
Brugia malayi cell division control protein 2 homolog 0.0181268 0.0462152 0.0391109
Schistosoma mansoni serine/threonine protein kinase 0.0181268 0.0462152 0.0544257
Trypanosoma cruzi cyclin, putative 0.0384625 0.206788 1
Trichomonas vaginalis cyclin B, putative 0.0384625 0.206788 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0289815 0.131925 0.183054
Trichomonas vaginalis cyclins, putative 0.0384625 0.206788 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0289815 0.131925 0.183054
Echinococcus granulosus cyclins 0.0338941 0.170716 0.236878
Entamoeba histolytica cyclin, putative 0.0384625 0.206788 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0486204 0.286996 0.281685
Leishmania major protein kinase A catalytic subunit 0.0289815 0.131925 0.62455
Loa Loa (eye worm) AGC/PKA protein kinase 0.0289815 0.131925 0.12546
Trypanosoma brucei cdc2-related kinase 3 0.0181268 0.0462152 0.194698
Echinococcus multilocularis cyclin dependent kinase 1 0.0181268 0.0462152 0.0641262
Loa Loa (eye worm) hypothetical protein 0.0171904 0.0388217 0.0316624
Trichomonas vaginalis cyclins, putative 0.0384625 0.206788 1
Loa Loa (eye worm) cyclin domain-containing protein 0.138919 1 1
Leishmania major cyclin 0.0384625 0.206788 1
Trichomonas vaginalis cyclin B, putative 0.0384625 0.206788 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0486204 0.286996 0.281685
Schistosoma mansoni cyclin B 0.0384625 0.206788 0.279539
Leishmania major protein kinase A catalytic subunit isoform 2 0.0289815 0.131925 0.62455
Leishmania major protein kinase A catalytic subunit isoform 1 0.0289815 0.131925 0.62455
Entamoeba histolytica cyclin, putative 0.0338941 0.170716 0.819092
Loa Loa (eye worm) hypothetical protein 0.0384625 0.206788 0.20088
Entamoeba histolytica cell division protein kinase 2, putative 0.0181268 0.0462152 0.194698
Echinococcus granulosus cyclin b3 0.0338941 0.170716 0.236878

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Neurotoxicity in mouse at 300 mg/kg after 0.5 hrs ChEMBL. 18282710
Activity (ADMET) Neurotoxicity in mouse at 100 mg/kg after 0.5 hrs ChEMBL. 18282710
Activity (ADMET) Neurotoxicity in mouse at 100 mg/kg after 4 hrs ChEMBL. 18282710
Activity (ADMET) Neurotoxicity in mouse at 300 mg/kg after 4 hrs ChEMBL. 18282710
AP (functional) = 11.5 Average potency of all four cell lines (P388 cell line, L1210 cell line, Molt 4/C8 cell line, CEM T-lymphocytes) ChEMBL. 11170648
CC50 (functional) = 0.9 uM Cytotoxicity against human HSC2 by MTT method ChEMBL. 17499885
CC50 (functional) = 3.6 uM Cytotoxicity against human HL60 cells in presence of RPMI1640 containing 10% fetal bovine serum by trypan blue exclusion test ChEMBL. 17499885
CC50 (functional) = 6.1 uM Cytotoxicity against human HSC4 cells by MTT method ChEMBL. 17499885
GI50 (functional) -7.025 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.68 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.335 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.267 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.21 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.203 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.965 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.911 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.656 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.333 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 41.2 ng/ml Antimalarial activity against drug-resistant Plasmodium falciparum C235 after 72 hrs by SYBR green I staining-based fluorescence assay ChEMBL. 24139941
IC50 (functional) = 356 ng/ml Antimalarial activity against liver stage Plasmodium berghei ANKA sporozoites infected in human HepG2 cells after 48 hrs by luciferase reporter gene assay ChEMBL. 24139941
IC50 (ADMET) > 2000 ng/ml Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay ChEMBL. 24139941
IC50 (functional) = 0.2 uM Cytotoxicity against murine P388 cells. ChEMBL. 11170648
IC50 (functional) = 0.2 uM Cytotoxicity against murine P388 cells. ChEMBL. 11170648
IC50 (functional) = 0.4 uM Cytotoxicity against human A549 cells after 72 hrs by MTT assay ChEMBL. 19046794
IC50 (functional) = 1.54 uM Cytotoxicity against human PC3 cells after 72 hrs by MTT assay ChEMBL. 19046794
IC50 (functional) = 2.5 uM Cytotoxicity against human Scov3 cells after 72 hrs by MTT assay ChEMBL. 19046794
IC50 (functional) = 4.47 uM Cytotoxicity against CEM T-lymphocytes. ChEMBL. 11170648
IC50 (functional) = 4.47 uM Cytotoxicity against CEM T-lymphocytes. ChEMBL. 11170648
IC50 (functional) = 4.47 uM Cytotoxicity against human CEM cells ChEMBL. 19819135
IC50 (functional) = 8.28 uM Cytotoxicity against human Molt 4/C8 cells. ChEMBL. 11170648
IC50 (functional) = 32.09 uM Cytotoxicity against mouse L1210 cells ChEMBL. 19819135
IC50 (functional) = 32.9 uM Cytotoxicity against murine L1210 cells. ChEMBL. 11170648
IC50 (functional) = 32.9 uM Cytotoxicity against murine L1210 cells. ChEMBL. 11170648
IC50 (functional) = 214 uM Inhibitory effect of the compound on the biosyntheses of protein in murine L1210 cells. ChEMBL. 11170648
IC50 (functional) = 214 uM Inhibitory effect of the compound on the biosyntheses of protein in murine L1210 cells. ChEMBL. 11170648
IC50 (functional) = 228 uM Inhibitory effect of the compound on the biosyntheses of DNA in murine L1210 cells. ChEMBL. 11170648
IC50 (functional) = 228 uM Inhibitory effect of the compound on the biosyntheses of DNA in murine L1210 cells. ChEMBL. 11170648
IC50 (functional) = 276 uM Inhibitory effect of the compound on the biosyntheses of RNA in murine L1210 cells. ChEMBL. 11170648
IC50 (functional) = 276 uM Inhibitory effect of the compound on the biosyntheses of RNA in murine L1210 cells. ChEMBL. 11170648
Inhibition (functional) = 100 % Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 12.5 ug/ml by broth microdilution assay ChEMBL. 18282710
LogP = 3.27 Lipophilicity, log P of the compound ChEMBL. 18513966
MIC (functional) = 0.2 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by broth microdilution assay ChEMBL. 18282710
Ratio (binding) = 0.8 Reversal of P-glycoprotein-mediated multidrug resistance in human MDR1 gene transfected mouse L5178Y cells assessed as fluorescence activity ratio at 40 ug/ml by flow cytometry ChEMBL. 18513966
Ratio (binding) = 0.92 Inhibition of human MDR1 transfected in mouse L5178Y cells assessed as fluorescence activity ratio at 40 ug/ml after 10 mins by rhodamine 123 dye based fluorescence analysis ChEMBL. 26796064
Ratio (binding) = 1.04 Reversal of P-glycoprotein-mediated multidrug resistance in human MDR1 gene transfected mouse L5178Y cells assessed as fluorescence activity ratio at 4 ug/ml by flow cytometry ChEMBL. 18513966
Ratio (binding) = 2.19 Inhibition of human MDR1 transfected in mouse L5178Y cells assessed as fluorescence activity ratio at 4 ug/ml after 10 mins by rhodamine 123 dye based fluorescence analysis ChEMBL. 26796064
Ratio (binding) = 0.8 Reversal of P-glycoprotein-mediated multidrug resistance in human MDR1 gene transfected mouse L5178Y cells assessed as fluorescence activity ratio at 40 ug/ml by flow cytometry ChEMBL. 18513966
Ratio (binding) = 1.04 Reversal of P-glycoprotein-mediated multidrug resistance in human MDR1 gene transfected mouse L5178Y cells assessed as fluorescence activity ratio at 4 ug/ml by flow cytometry ChEMBL. 18513966
Ratio IC50 (functional) = 1.1 Ratio of IC50 for drug-resistant Plasmodium falciparum C235 to IC50 for drug-sensitive Plasmodium falciparum D6 ChEMBL. 24139941
T1/2 (ADMET) = 22.5 min Half life in mouse plasma at 1 mM by LC/MS analysis ChEMBL. 24139941
T1/2 (ADMET) > 60 min Half life in human plasma at 1 mM by LC/MS analysis ChEMBL. 24139941

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11170648
Plasmodium falciparum ChEMBL23 24139941
Plasmodium berghei ChEMBL23 24139941
Mus musculus ChEMBL23 11170648

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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