Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | isoleucine--tRNA ligase, putative | 0.0087 | 0.0586 | 0.5 |
Trypanosoma cruzi | isoleucyl-tRNA synthetase, putative | 0.0087 | 0.0586 | 0.5 |
Chlamydia trachomatis | isoleucine--tRNA ligase | 0.0087 | 0.0586 | 0.5 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0581 | 1 | 1 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0087 | 0.0586 | 0.5 |
Leishmania major | isoleucyl-tRNA synthetase, putative | 0.0087 | 0.0586 | 0.5 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.0087 | 0.0586 | 0.5 |
Mycobacterium leprae | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) | 0.0185 | 0.246 | 0.1991 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.0087 | 0.0586 | 0.5 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0216 | 0.3046 | 1 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0185 | 0.246 | 0.1991 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0087 | 0.0586 | 0.5 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0087 | 0.0586 | 0.5 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0087 | 0.0586 | 0.5 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0581 | 1 | 1 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0581 | 1 | 1 |
Brugia malayi | isoleucyl-tRNA synthetase | 0.0087 | 0.0586 | 0.5 |
Onchocerca volvulus | 0.0068 | 0.0234 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | formamidopyrimidine-DNA glycosylase | 0.0185 | 0.246 | 1 |
Mycobacterium tuberculosis | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) | 0.0185 | 0.246 | 0.246 |
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.0087 | 0.0586 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0586 | 1 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0087 | 0.0586 | 1 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0185 | 0.246 | 0.1991 |
Trypanosoma brucei | isoleucyl-tRNA synthetase, putative | 0.0087 | 0.0586 | 0.5 |
Mycobacterium tuberculosis | Possible DNA glycosylase | 0.0185 | 0.246 | 0.246 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0087 | 0.0586 | 1 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0087 | 0.0586 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Effect on second messenger (PI or cGMP) turnover at human neurotensin receptor; ND=Not determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.