Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.319 | 0.319 |
Brugia malayi | RNA binding protein | 0.0073 | 0.319 | 0.3373 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.319 | 0.3373 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.3744 | 0.3744 |
Echinococcus multilocularis | geminin | 0.0183 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3744 | 0.3744 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.3744 | 0.3744 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1235 | 0.5 |
Onchocerca volvulus | 0.0174 | 0.9458 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.319 | 0.319 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3744 | 0.3958 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3744 | 0.3958 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1235 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.319 | 0.3373 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.3744 | 0.3744 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.319 | 0.319 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.319 | 0.3373 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1235 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.319 | 0.319 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3744 | 0.3958 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.3744 | 0.3958 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.9458 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1235 | 0.1235 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0174 | 0.9458 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1235 | 0.1235 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.319 | 0.319 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.319 | 0.319 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3744 | 0.3958 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3744 | 0.3744 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.319 | 0.319 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3744 | 0.3744 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3744 | 0.3744 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.319 | 0.3373 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.319 | 0.3373 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.3744 | 0.3958 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1235 | 0.1306 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1235 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 7.16 | Inhibition of acetylcholinesterase. | ChEMBL. | 1738151 |
IC50 (binding) | = 7.16 | Inhibition of acetylcholinesterase. | ChEMBL. | 1738151 |
IC50 (binding) | = 380 nM | IC50 against acetylcholinesterase; value ranges from 1.3-380 nM. | ChEMBL. | 1738151 |
IC50 (binding) | = 380 nM | IC50 against acetylcholinesterase; value ranges from 1.3-380 nM. | ChEMBL. | 1738151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.