Detailed information for compound 265824

Basic information

Technical information
  • TDR Targets ID: 265824
  • Name: 2-(tert-butylamino)-1-(3-chlorophenyl)propan- 1-ol
  • MW: 241.757 | Formula: C13H20ClNO
  • H donors: 2 H acceptors: 1 LogP: 2.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(c1cccc(c1)Cl)O)NC(C)(C)C
  • InChi: 1S/C13H20ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,12,15-16H,1-4H3
  • InChiKey: NDPTTXIBLSWNSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(tert-butylamino)-1-(3-chlorophenyl)-1-propanol
  • hydrobupropion
  • CPD-3482
  • erythrohydrobupropion
  • threohydrobupropion
  • CPD-3484

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus granulosus neuropeptides capa receptor 0.025 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Schistosoma mansoni peroxidasin 0.0152 0.5169 0.5169
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Brugia malayi Animal haem peroxidase family protein 0.0152 0.5169 0.5169
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.025 1 1
Schistosoma mansoni endoplasmin 0.0116 0.3395 0.3395
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0093 0.2224 0.5
Echinococcus multilocularis heat shock protein 0.0116 0.3395 0.3395
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.025 1 1
Schistosoma mansoni amine GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Brugia malayi Tachykinin-like peptides receptor 99D 0.025 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.025 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.025 1 1
Onchocerca volvulus Peroxidase homolog 0.0152 0.5169 0.5169
Echinococcus multilocularis endoplasmin 0.0093 0.2224 0.2224
Echinococcus granulosus rhodopsin orphan GPCR 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Onchocerca volvulus 0.025 1 1
Brugia malayi hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Brugia malayi hypothetical protein 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Schistosoma mansoni amine GPCR 0.025 1 1
Brugia malayi Serotonin receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Brugia malayi GnHR receptor homolog 0.025 1 1
Echinococcus granulosus neuropeptide receptor 0.025 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.025 1 1
Schistosoma mansoni opsin-like receptor 0.025 1 1
Onchocerca volvulus 0.025 1 1
Echinococcus multilocularis heat shock protein 90 0.0116 0.3395 0.3395
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.025 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.025 1 1
Onchocerca volvulus 0.0152 0.5169 0.5169
Echinococcus granulosus neuropeptides capa receptor 0.025 1 1
Brugia malayi hypothetical protein 0.025 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.025 1 1
Onchocerca volvulus 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.025 1 1
Echinococcus granulosus g protein coupled receptor 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0116 0.3395 1
Onchocerca volvulus Peroxidase homolog 0.0152 0.5169 0.5169
Brugia malayi Animal haem peroxidase family protein 0.0152 0.5169 0.5169
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.025 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.025 1 1
Onchocerca volvulus 0.025 1 1
Echinococcus granulosus somatostatin receptor 0.025 1 1
Echinococcus multilocularis fmrfamide receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.025 1 1
Echinococcus multilocularis fmrfamide receptor 0.025 1 1
Onchocerca volvulus Peroxidasin homolog 0.0152 0.5169 0.5169
Echinococcus granulosus sex peptide receptor 0.025 1 1
Echinococcus granulosus serotonin receptor 0.025 1 1
Treponema pallidum heat shock protein 90 0.0093 0.2224 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Echinococcus granulosus peroxidasin 0.0152 0.5169 0.5169
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.025 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Echinococcus granulosus heat shock protein 0.0116 0.3395 0.3395
Trichomonas vaginalis heat shock protein, putative 0.0071 0.1171 0.345
Echinococcus multilocularis g-protein coupled receptor 0.025 1 1
Echinococcus granulosus endoplasmin 0.0093 0.2224 0.2224
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Toxoplasma gondii heat shock protein HSP90 0.0116 0.3395 1
Trypanosoma brucei heat shock protein 90, putative 0.0116 0.3395 1
Schistosoma mansoni growth hormone secretagogue receptor 0.025 1 1
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.025 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0152 0.5169 0.5169
Schistosoma mansoni amine GPCR 0.025 1 1
Echinococcus granulosus heat shock protein 90 0.0093 0.2224 0.2224
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus multilocularis neuropeptide receptor 0.025 1 1
Schistosoma mansoni biogenic amine receptor 0.025 1 1
Brugia malayi Dopamine receptor protein 2 0.025 1 1
Brugia malayi Dopamine receptor 0.025 1 1
Trichomonas vaginalis heat shock protein, putative 0.0093 0.2224 0.655
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.025 1 1
Brugia malayi hypothetical protein 0.025 1 1
Onchocerca volvulus 0.025 1 1
Brugia malayi G protein-coupled receptor 0.025 1 1
Echinococcus granulosus neuropeptide s receptor 0.025 1 1
Echinococcus granulosus allatostatin A receptor 0.025 1 1
Brugia malayi RE15519p 0.025 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.025 1 1
Onchocerca volvulus 0.025 1 1
Trypanosoma brucei heat shock protein 90, putative 0.0116 0.3395 1
Schistosoma mansoni adenoreceptor 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Trichomonas vaginalis heat shock protein, putative 0.0116 0.3395 1
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Echinococcus granulosus rhodopsin orphan GPCR 0.025 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.025 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.025 1 1
Brugia malayi Peroxidasin 0.0152 0.5169 0.5169
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.025 1 1
Trichomonas vaginalis endoplasmin, putative 0.0071 0.1171 0.345
Echinococcus multilocularis dro:myosuppressin receptor 0.025 1 1
Brugia malayi hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni heat shock protein 0.0116 0.3395 0.3395
Plasmodium vivax heat shock protein 86, putative 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.0152 0.5169 0.5169
Echinococcus multilocularis neuropeptide Y receptor 0.025 1 1
Echinococcus multilocularis sex peptide receptor 0.025 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.025 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Trypanosoma cruzi heat shock protein 90, putative 0.0116 0.3395 1
Schistosoma mansoni biogenic amine receptor 0.025 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.025 1 1
Onchocerca volvulus 0.0152 0.5169 0.5169
Loa Loa (eye worm) animal heme peroxidase 0.0152 0.5169 0.5169
Loa Loa (eye worm) blistered cuticle protein 3 0.0152 0.5169 0.5169
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.2224 0.655
Brugia malayi neuropeptide F receptor 0.025 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.025 1 1
Brugia malayi hypothetical protein 0.025 1 1
Brugia malayi G-protein coupled receptor 0.025 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.025 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Schistosoma mansoni neuropeptide receptor 0.025 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.025 1 1
Brugia malayi AKH receptor 0.025 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0069 0.1038 0.3058
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Echinococcus granulosus 7tm_1 domain containing protein 0.025 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.025 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.025 1 1
Brugia malayi Animal haem peroxidase family protein 0.0152 0.5169 0.5169
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus multilocularis g protein coupled receptor 0.025 1 1
Echinococcus granulosus g protein coupled receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Schistosoma mansoni alpha-1 adrenergic receptor 0.025 1 1
Brugia malayi hypothetical protein 0.025 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.025 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.025 1 1
Echinococcus multilocularis serotonin receptor 0.025 1 1
Schistosoma mansoni hypothetical protein 0.025 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.025 1 1
Echinococcus granulosus heat shock protein 90 0.0116 0.3395 0.3395
Echinococcus granulosus neuropeptide FF receptor 2 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.025 1 1
Schistosoma mansoni opsin-like receptor 0.025 1 1
Brugia malayi Blistered cuticle protein 3 0.0152 0.5169 0.5169
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Onchocerca volvulus 0.025 1 1
Brugia malayi follicle stimulating hormone receptor 0.025 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.025 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.025 1 1
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Echinococcus granulosus hypothetical protein 0.025 1 1
Onchocerca volvulus 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Echinococcus granulosus g-protein coupled receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) TYRA-2 protein 0.025 1 1
Echinococcus multilocularis serotonin receptor 0.025 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.025 1 1
Trypanosoma brucei Heat shock protein 83, putative 0.0116 0.3395 1
Echinococcus multilocularis g protein coupled receptor 0.025 1 1
Schistosoma mansoni hypothetical protein 0.025 1 1
Brugia malayi Endoplasmin precursor 0.0116 0.3395 0.3395
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.025 1 1
Plasmodium falciparum heat shock protein 90 0.0116 0.3395 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0116 0.3395 1
Trypanosoma cruzi heat shock protein 85, putative 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0093 0.2224 0.655
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Schistosoma mansoni neuropeptide F-like receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.025 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Brugia malayi sulfakinin receptor protein 0.025 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.025 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.025 1 1
Brugia malayi Dopamine receptor protein 1 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Brugia malayi hypothetical protein 0.0152 0.5169 0.5169
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Onchocerca volvulus 0.0152 0.5169 0.5169
Mycobacterium ulcerans heat shock protein 90 0.0093 0.2224 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.025 1 1
Loa Loa (eye worm) heat shock protein 90 0.0116 0.3395 0.3395
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Brugia malayi hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.025 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.025 1 1
Brugia malayi Animal haem peroxidase family protein 0.0152 0.5169 0.5169
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.025 1 1
Schistosoma mansoni hypothetical protein 0.025 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.025 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.025 1 1
Onchocerca volvulus Dual oxidase homolog 0.0152 0.5169 0.5169
Echinococcus multilocularis biogenic amine (5HT) receptor 0.025 1 1
Schistosoma mansoni endoplasmin 0.0116 0.3395 0.3395
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni peroxidasin 0.0152 0.5169 0.5169
Schistosoma mansoni amine GPCR 0.025 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Brugia malayi Melatonin receptor type 1A 0.025 1 1
Echinococcus multilocularis neuropeptide receptor 0.025 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0152 0.5169 0.5169
Onchocerca volvulus 0.025 1 1
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Echinococcus multilocularis heat shock protein 90 0.0093 0.2224 0.2224
Echinococcus multilocularis peroxidasin 0.0152 0.5169 0.5169
Echinococcus granulosus biogenic amine 5HT receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Echinococcus granulosus neuropeptide receptor A26 0.025 1 1
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Loa Loa (eye worm) endoplasmin 0.0116 0.3395 0.3395
Brugia malayi Serotonin/octopamine receptor family protein 7 0.025 1 1
Echinococcus multilocularis orexin receptor type 2 0.025 1 1
Schistosoma mansoni histamine h1 receptor 0.025 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni neuropeptide receptor 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.025 1 1
Schistosoma mansoni neuropeptide receptor 0.025 1 1
Echinococcus granulosus g protein coupled receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0152 0.5169 0.5169
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.025 1 1
Onchocerca volvulus 0.025 1 1
Onchocerca volvulus 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Brugia malayi heat shock protein 90 0.0116 0.3395 0.3395
Entamoeba histolytica heat shock protein 90, putative 0.0116 0.3395 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.025 1 1
Schistosoma mansoni myosin xvIII 0.025 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Onchocerca volvulus 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Brugia malayi Serotonin receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Plasmodium vivax endoplasmin, putative 0.0116 0.3395 1
Brugia malayi hypothetical protein 0.025 1 1
Echinococcus granulosus orexin receptor type 2 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.025 1 1
Echinococcus granulosus neuropeptide Y receptor 0.025 1 1
Schistosoma mansoni biogenic amine receptor 0.025 1 1
Echinococcus multilocularis allatostatin A receptor 0.025 1 1
Schistosoma mansoni heat shock protein 0.0116 0.3395 0.3395
Trypanosoma cruzi heat shock protein 90, putative 0.0093 0.2224 0.655
Onchocerca volvulus 0.025 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.025 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.025 1 1
Brugia malayi neuropeptide F receptor 0.025 1 1
Brugia malayi Animal haem peroxidase family protein 0.0152 0.5169 0.5169
Toxoplasma gondii heat shock protein 90, putative 0.0116 0.3395 1
Echinococcus multilocularis neuropeptide s receptor 0.025 1 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0093 0.2224 0.5
Brugia malayi larval opioid receptor 0.025 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.025 1 1
Brugia malayi putative neuropeptide receptor 0.025 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Onchocerca volvulus Peroxidasin homolog 0.0152 0.5169 0.5169
Plasmodium falciparum endoplasmin, putative 0.0071 0.1171 0.345
Schistosoma mansoni rhodopsin-like orphan GPCR 0.025 1 1
Onchocerca volvulus 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus granulosus neuropeptide receptor 0.025 1 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0093 0.2224 0.5
Schistosoma mansoni hypothetical protein 0.025 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.025 1 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0093 0.2224 0.2224
Onchocerca volvulus 0.025 1 1
Echinococcus granulosus G protein coupled receptor 139 0.025 1 1
Brugia malayi ORL1-like opioid receptor 0.025 1 1
Trypanosoma brucei heat shock protein, putative 0.0116 0.3395 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.025 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.025 1 1
Onchocerca volvulus 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Echinococcus multilocularis neuropeptide Y receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.025 1 1
Schistosoma mansoni neuropeptide receptor 0.025 1 1
Echinococcus granulosus neuropeptide Y receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Brugia malayi G-protein coupled receptor 0.025 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Echinococcus multilocularis somatostatin receptor 0.025 1 1
Entamoeba histolytica heat shock protein 90, putative 0.0116 0.3395 1
Echinococcus granulosus fmrfamide receptor 0.025 1 1
Schistosoma mansoni opsin-like receptor 0.025 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.025 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.025 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.5169 0.5169
Echinococcus multilocularis g protein coupled receptor 0.025 1 1
Onchocerca volvulus 0.025 1 1
Leishmania major heat shock protein 83-1 0.0116 0.3395 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.025 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.025 1 1
Trichomonas vaginalis heat shock protein, putative 0.0093 0.2224 0.655
Trichomonas vaginalis heat shock protein, putative 0.0093 0.2224 0.655

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) mg kg-1 Anticonvulsant activity of compound was tested in mice after intraperitoneal administration in Maximal electroshock assay (MES); ND=No data ChEMBL. No reference
ED50 (functional) 0 mg kg-1 Anticonvulsant activity of compound was tested in mice after intraperitoneal administration in Maximal electroshock assay (MES); ND=No data ChEMBL. No reference
ED50 (functional) = 11 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference
ED50 (functional) = 11 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference
ED50 (functional) = 14 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference
ED50 (functional) = 14 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference
ED50 (functional) = 26 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference
ED50 (functional) = 26 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference
ED50 (functional) = 28 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference
ED50 (functional) = 28 mg kg-1 Anticonvulsant activity measured in Maximal electroshock assay (MES), intraperitoneal administration ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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