Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1787 | 1 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0029 | 0.0006 | 0.0006 |
Echinococcus multilocularis | thymidylate synthase | 0.1787 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0029 | 0.0006 | 0.0006 |
Echinococcus granulosus | thymidylate synthase | 0.1787 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1787 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1787 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1787 | 1 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0029 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | thymidylate synthase | 0.1787 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0029 | 0.0006 | 0.0006 |
Trichomonas vaginalis | conserved hypothetical protein | 0.085 | 0.4673 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0408 | 0.0408 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1787 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1787 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1787 | 1 | 1 |
Onchocerca volvulus | 0.1787 | 1 | 0.5 | |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0408 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0006 | 0.0006 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0029 | 0.0006 | 0.0006 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0029 | 0.0006 | 0.0006 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1787 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1787 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.1787 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.085 | 0.4673 | 0.467 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 27 uM | Cellular cytotoxicity of the compound against human lymphocytic cell lines H-9. | ChEMBL. | 14667230 |
CC50 (functional) | = 27 uM | Cellular cytotoxicity of the compound against human lymphocytic cell lines H-9. | ChEMBL. | 14667230 |
CC50 (functional) | = 29 uM | Cellular cytotoxicity of the compound was determined in normal mouse spleen stimulated with concanavalin A | ChEMBL. | 14667230 |
CC50 (functional) | = 29 uM | Cellular cytotoxicity of the compound was determined in normal mouse spleen stimulated with concanavalin A | ChEMBL. | 14667230 |
IC50 (binding) | = 3 uM | Inhibitory activity of the compound against HIV-reverse transcriptase (HIV-RT) | ChEMBL. | 14667230 |
IC50 (binding) | = 3 uM | Inhibitory activity of the compound against HIV-reverse transcriptase (HIV-RT) | ChEMBL. | 14667230 |
IC50 (functional) | = 6.8 uM | Cytotoxicity towards BE-NQ (NQO1-rich) human colon adenocarcinoma cell line | ChEMBL. | 16302813 |
IC50 (functional) | = 6.8 uM | Cytotoxicity towards BE-NQ (NQO1-rich) human colon adenocarcinoma cell line | ChEMBL. | 16302813 |
IC50 (functional) | = 8.1 uM | Cytotoxicity towards BE-WT (NQO1-deficient) human colon adenocarcinoma cell line | ChEMBL. | 16302813 |
IC50 (functional) | = 8.1 uM | Cytotoxicity towards BE-WT (NQO1-deficient) human colon adenocarcinoma cell line | ChEMBL. | 16302813 |
MET (ADMET) | = 15.4 umol/min/mg | Metabolism by recombinant human NQO1 monitored by spectrophotometric cytochrome assay | ChEMBL. | 16302813 |
MET (ADMET) | = 15.4 umol/min/mg | Metabolism by recombinant human NQO1 monitored by spectrophotometric cytochrome assay | ChEMBL. | 16302813 |
Ratio IC50 (functional) | = 1.2 | Selectivity for BE-WT cell line over the BE-NQ cell line | ChEMBL. | 16302813 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16302813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.